Inclusion of patients with brain metastases in phase I trials: An unmet need Journal Article
| Authors: | Gounder, M. M.; Spriggs, D. R. |
| Article Title: | Inclusion of patients with brain metastases in phase I trials: An unmet need |
| Abstract: | Patients with brain metastases are increasing in number; however, these patients are often excluded in phase I/II trials due to perceived poor prognosis, risk of hemorrhage, inefficient drug delivery, and confounding toxicities. Tsimberidou and colleagues demonstrate that selected patients can be appropriately enrolled in phase I trials and have outcomes representative of the general cancer population. ©2011 AACR. |
| Keywords: | treatment failure; overall survival; cytotoxic agent; drug efficacy; drug safety; note; cancer radiotherapy; fever; brain metastasis; phase 1 clinical trial (topic) |
| Journal Title: | Clinical Cancer Research |
| Volume: | 17 |
| Issue: | 12 |
| ISSN: | 1078-0432 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2011-06-15 |
| Start Page: | 3855 |
| End Page: | 3857 |
| Language: | English |
| DOI: | 10.1158/1078-0432.ccr-11-0759 |
| PROVIDER: | scopus |
| PUBMED: | 21527561 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 17 August 2011" - "CODEN: CCREF" - "Source: Scopus" |
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