Outcome of patients treated surgically for lymph node metastases from cutaneous squamous cell carcinoma of the head and neck Journal Article
| Authors: | Givi, B.; Andersen, P. E.; Diggs, B. S.; Wax, M. K.; Gross, N. D. |
| Article Title: | Outcome of patients treated surgically for lymph node metastases from cutaneous squamous cell carcinoma of the head and neck |
| Abstract: | Background There is a paucity of outcomes data for patients with lymph node metastasis from cutaneous squamous cell carcinoma of head and neck (SCCHN). Methods Patients from a tertiary care center with cutaneous SCCHN metastatic to parotid and or cervical lymph nodes were identified. Data were abstracted and analyzed using COX multivariate analysis. Results Fifty-one patients (47 men, and 4 women) with a median age of 73 years were identified. Eight patients (16%) had recurrent disease and 11 (22%) were immunosuppressed. Forty patients (71%) received adjuvant radiation therapy. Median overall survival was 23 months (range, 3-148 months). Recurrent disease was associated with higher risk of death (hazard ratio [HR], 2.7; 95% confidence interval [CI] 1.1-6.9) and radiation therapy with reduced risk (HR, 0.18; 95% CI, 0.06-0.54). Conclusion Lymph node metastases from cutaneous SCCHN is associated with poor survival. © 2011 Wiley Periodicals, Inc. Head Neck, 2011 Copyright © 2011 Wiley Periodicals, Inc. |
| Keywords: | survival; adult; cancer survival; treatment outcome; aged; aged, 80 and over; middle aged; major clinical study; neck dissection; squamous cell carcinoma; carcinoma, squamous cell; cancer radiotherapy; radiotherapy, adjuvant; recurrent cancer; lymph node metastasis; lymphatic metastasis; neoplasm recurrence, local; skin neoplasms; skin cancer; death; head and neck neoplasms; multivariate analysis; neoplasm invasiveness; cervical lymph node; immunosuppressive treatment; head and neck; parotid neoplasms; head and neck carcinoma; cervical metastasis; parotidectomy |
| Journal Title: | Head & Neck |
| Volume: | 33 |
| Issue: | 7 |
| ISSN: | 1043-3074 |
| Publisher: | John Wiley & Sons, Inc. |
| Date Published: | 2011-07-01 |
| Start Page: | 999 |
| End Page: | 1004 |
| Language: | English |
| DOI: | 10.1002/hed.21574 |
| PROVIDER: | scopus |
| PUBMED: | 21284049 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 17 August 2011" - "CODEN: HEANE" - "Source: Scopus" |
