Combinatorial antigen targeting: Ideal T-cell sensing and anti-tumor response Journal Article
| Authors: | Themelil, M.; Sadelain, M. |
| Article Title: | Combinatorial antigen targeting: Ideal T-cell sensing and anti-tumor response |
| Abstract: | T cells expressing chimeric antigen receptors (CARs) are a formidable platform for the study and application of synthetic biology approaches to study customized and flexible control of cellular functions. Recent reports in the journal Cell provide a new twist on combinatorial antigen targeting, profiting from the singular cleavage and signaling of the Notch receptor to conditionally express CARs. |
| Keywords: | therapy; notch; receptors |
| Journal Title: | Trends in Molecular Medicine |
| Volume: | 22 |
| Issue: | 4 |
| ISSN: | 1471-4914 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2016-04-01 |
| Start Page: | 271 |
| End Page: | 273 |
| Language: | English |
| ACCESSION: | WOS:000374612200003 |
| DOI: | 10.1016/j.molmed.2016.02.009 |
| PROVIDER: | wos |
| PUBMED: | 26971630 |
| PMCID: | PMC4994806 |
| Notes: | Editorial Material -- Source: Wos |
