Impact of elective neck dissection on the outcome of oral squamous cell carcinomas arising in the maxillary alveolus and hard palate Journal Article

   


Authors: Givi, B.; Eskander, A.; Awad, M. I.; Kong, Q.; Montero, P. H.; Palmer, F. L.; Xu, W.; De Almeida, J. R.; Lee, N.; O'Sullivan, B.; Irish, J. C.; Gilbert, R. W.; Ganly, I.; Patel, S. G.; Goldstein, D. P.; Morris, L. G. T.
Article Title: Impact of elective neck dissection on the outcome of oral squamous cell carcinomas arising in the maxillary alveolus and hard palate
Abstract: Background. Whether elective lymph neck dissection (ELND) is associated with improved survival in oral squamous cell carcinomas (SCC) of the maxillary alveolus/hard palate is not known. Methods. One hundred ninety-nine patients presenting de novo and receiving treatment for clinically node negative SCC of the maxillary alveolus/hard palate at 2 cancer centers between 1985 and 2011 were analyzed. Results. Forty-two patients (21%) received ELND. Occult nodal metastases were present in 29% of the dissected necks. The ELND group had more T3 to T4 status tumors (62% vs 34%; p < .001) and positive-margin resections (59% vs 38%; p 5.019). Patients undergoing ELND experienced lower rates of neck recurrence (6% vs 21%; p = .031), superior 5-year recurrence-free survival (68% vs 45%; p = .026), and overall survival (86% vs 62%; p = .043). ELND was associated with a 2-fold decrease in risk of recurrence in multivariable analysis. Conclusion. ELND was associated with lower rates of recurrence and improved survival in SCC of the maxillary alveolus/hard palate. (C) 2015 Wiley Periodicals, Inc.
Keywords: treatment outcome; neck dissection; disease free survival; lymphatic metastasis; palate; maxillary neoplasms; epidermoid carcinoma; cancer; hard; squamous cell carcinoma of head and neck
Journal Title: Head & Neck
Volume: 38
Issue: Suppl. 1
ISSN: 1043-3074
Publisher: John Wiley & Sons, Inc.  
Date Published: 2016-04-01
Start Page: E1688
End Page: E1694
Language: English
ACCESSION: WOS:000375116400218
DOI: 10.1002/hed.24302
PROVIDER: wos
PUBMED: 26614119
PMCID: PMC4927080
Notes: Article -- Source: Wos
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MSK Authors
  1. Snehal G Patel
    412 Patel
  2. Nancy Y. Lee
    871 Lee
  3. Luc Morris
    278 Morris
  4. Pablo Hernan Montero Miranda
    22 Montero Miranda
  5. Ian Ganly
    430 Ganly
  6. Frank Palmer
    82 Palmer
  7. Mahmoud Issam Awad
    10 Awad
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