Transplant for MDS: Challenges and emerging strategies Journal Article

  


Authors: Tamari, R.; Castro-Malaspina, H.
Article Title: Transplant for MDS: Challenges and emerging strategies
Abstract: Allogeneic hematopoietic stem cell transplantation is the only curative treatment for myelodysplastic syndrome. Major improvements in the field of allogeneic stem cell transplantation have made it a better tolerated treatment that can be offered to older patients and patients with co-morbidities. However, treatment related toxicities, graft versus host disease, infectious complications and relapse remain major problems post transplant. With better understanding of disease biology and prognosis and with different types of conditioning regimens as well as different graft sources, a transplant strategy should be tailored to the individual host to maximize the benefits of this procedure. © 2014 Elsevier Ltd.
Keywords: survival; adult; aged; middle aged; survival analysis; treatment failure; transplantation, homologous; leukemia, myeloid, acute; disease course; mortality; antineoplastic agents; antineoplastic agent; quality of life; relapse; recurrence; hematopoietic stem cell transplantation; transplantation; age; immunology; hla matching; myeloablative conditioning; myelodysplastic syndrome; disease progression; diagnosis; comorbidity; graft versus host reaction; transplantation conditioning; recurrent disease; allogeneic hematopoietic stem cell transplantation; drug therapy; t cell depletion; immunosuppressive treatment; graft vs host disease; methods; therapy; allotransplantation; myelodysplastic syndromes; opportunistic infections; prevention and control; infectious complication; prevention; major histocompatibility antigen; procedures; therapeutic use; humans; prognosis; human; priority journal; article; allogeneic hematopoietic stem cell
Journal Title: Best Practice and Research: Clinical Haematology
Volume: 28
Issue: 1
ISSN: 1521-6926
Publisher: Elsevier Inc.  
Date Published: 2015-03-01
Start Page: 43
End Page: 54
Language: English
DOI: 10.1016/j.beha.2014.11.006
PUBMED: 25659729
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-84964222502&partnerID=40&md5=d5bb49c42b0888f499a14eed8b1edfbb
Notes: Article -- Export Date: 2 June 2016 -- Source: Scopus
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MSK Authors
  1. Hugo Castro-Malaspina
    333 Castro-Malaspina
  2. Roni Tamari
    210 Tamari
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