Costs of the detection of metastases and follow-up examinations in cutaneous melanoma Journal Article


Authors: Leiter, U.; Marghoob, A. A.; Lasithiotakis, K.; Eigentler, T. K.; Meier, F.; Meisner, C.; Garbe, C.
Article Title: Costs of the detection of metastases and follow-up examinations in cutaneous melanoma
Abstract: At present, no universally accepted recommendations exist for cutaneous melanoma follow-up. Various surveillance strategies, some associated with significant cost, others of uncertain value, are routinely used. This study aimed to evaluate of the costs incurred for varied surveillance strategies practiced in Europe and the USA. One thousand nine hundred and sixty-nine cutaneous melanoma patients with stage I-III disease attending the Department of Dermatology, University of Tuebingen for follow-up between 1996 and 1998 participated in the study. Routine surveillance consisted of cutaneous examination, lymph node and abdomen sonography, chest radiograph (CR) and blood tests. The costs incurred were based upon the 2004 German official scale for medical reimbursement and the 2004 Medicare fee reimbursement schedule (USA). The total charges were based on the number of recurrences detected per stage. Recurrences were detected in 1.5% of patients with stage 1,18.0% in stage II, and 68.6% in stage III. Physical examination was the most effective method, detecting 50.0% of recurrences. Lymph node sonography was effective in stage II-III, detecting 13.2% of recurrences; CR and abdominal sonography, detecting 4.5 and 3.4% of recurrences, were deemed beneficial in stage III. Blood tests detected 1.4% of recurrences and were deemed to be ineffective. Computed tomography scans were valuable in clarifying ambiguous findings and helping to detect 22.5% of recurrences (1.9% in stage I, 1.9% in stage II, and 18.6% in stage III). A risk-adapted surveillance strategy for stage I-II including thorough history, physical examination and lymph node sonography but omitting CR, blood work and abdomen sonography, seems appropriate and cost effective. © 2009 Wolters Kluwer Health|Lippincott Williams & Wilkins.
Keywords: controlled study; major clinical study; cancer recurrence; united states; cancer patient; follow up; follow-up studies; cancer diagnosis; neoplasm staging; diagnostic accuracy; prospective studies; melanoma; computer assisted tomography; skin neoplasms; europe; cost effectiveness analysis; health care cost; medicare; reimbursement; disease severity; blood sampling; diagnostic value; skin examination; lymph node; echography; neoplasm metastasis; thorax radiography; cancer epidemiology; physical examination; cutaneous melanoma; costs; follow-up schedule; recurrences; abdominal radiography; strategic planning; costs and cost analysis; diagnostic techniques and procedures
Journal Title: Melanoma Research
Volume: 19
Issue: 1
ISSN: 0960-8931
Publisher: Lippincott Williams & Wilkins  
Date Published: 2009-02-01
Start Page: 50
End Page: 57
Language: English
DOI: 10.1097/CMR.0b013e32831bc41c
PUBMED: 19430406
PROVIDER: scopus
DOI/URL:
Notes: --- - "Cited By (since 1996): 4" - "Export Date: 30 November 2010" - "CODEN: MREEE" - "Source: Scopus"
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  1. Ashfaq A Marghoob
    534 Marghoob