Exploiting the epigenome to control cancer-promoting gene-expression programs Journal Article
| Authors: | Brien, G. L.; Valerio, D. G.; Armstrong, S. A. |
| Article Title: | Exploiting the epigenome to control cancer-promoting gene-expression programs |
| Abstract: | The epigenome is a key determinant of transcriptional output. Perturbations within the epigenome are thought to be a key feature of many, perhaps all cancers, and it is now clear that epigenetic changes are instrumental in cancer development. The inherent reversibility of these changes makes them attractive targets for therapeutic manipulation, and a number of small molecules targeting chromatin-based mechanisms are currently in clinical trials. In this perspective we discuss how understanding the cancer epigenome is providing insights into disease pathogenesis and informing drug development. We also highlight additional opportunities to further unlock the therapeutic potential within the cancer epigenome. © 2016 Elsevier Inc. |
| Keywords: | chromatin; targeted therapy; histone modification; epigenome; cancer |
| Journal Title: | Cancer Cell |
| Volume: | 29 |
| Issue: | 4 |
| ISSN: | 1535-6108 |
| Publisher: | Cell Press |
| Date Published: | 2016-04-11 |
| Start Page: | 464 |
| End Page: | 476 |
| Language: | English |
| DOI: | 10.1016/j.ccell.2016.03.007 |
| PROVIDER: | scopus |
| PUBMED: | 27070701 |
| PMCID: | PMC4889129 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 2 May 2016 -- Source: Scopus |
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