Long noncoding RNAs in cancer pathways Journal Article


Authors: Schmitt, A. M.; Chang, H. Y.
Article Title: Long noncoding RNAs in cancer pathways
Abstract: Genome-wide cancer mutation analyses are revealing an extensive landscape of functional mutations within the noncoding genome, with profound effects on the expression of long noncoding RNAs (lncRNAs). While the exquisite regulation of lncRNA transcription can provide signals of malignant transformation, we now understand that lncRNAs drive many important cancer phenotypes through their interactions with other cellular macromolecules including DNA, protein, and RNA. Recent advancements in surveying lncRNA molecular mechanisms are now providing the tools to functionally annotate these cancer-associated transcripts, making these molecules attractive targets for therapeutic intervention in the fight against cancer. © 2016 Elsevier Inc.
Journal Title: Cancer Cell
Volume: 29
Issue: 4
ISSN: 1535-6108
Publisher: Cell Press  
Date Published: 2016-04-11
Start Page: 452
End Page: 463
Language: English
DOI: 10.1016/j.ccell.2016.03.010
PROVIDER: scopus
PMCID: PMC4831138
PUBMED: 27070700
DOI/URL:
Notes: Review -- Export Date: 2 May 2016 -- Source: Scopus
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  1. Adam Michael Schmitt
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