Inter-observer agreement on the assessment of relative liver lesion signal intensity on hepatobiliary phase imaging with gadoxetate (Gd-EOB-DTPA) Journal Article


Authors: Ngu, S.; Lebron-Zapata, L.; Pomeranz, C.; Katz, S.; Gerst, S.; Zheng, J.; Moskowitz, C.; Do, R. K. G.
Article Title: Inter-observer agreement on the assessment of relative liver lesion signal intensity on hepatobiliary phase imaging with gadoxetate (Gd-EOB-DTPA)
Abstract: Purpose: The purpose of the study was to assess the inter-observer agreement on the qualitative and quantitative evaluation of relative signal intensity of liver lesions on delayed hepatobiliary phase (HBP) MRI with gadoxetate (Gd-EOB-DTPA). Methods: 105 patients with liver lesions, who had delayed HPB MRI using gadoxetate were reviewed retrospectively. For each patient, four readers (two fellows in training and two attending radiologists) qualitatively assessed the relative SI of the largest representative lesion on a five point scale, and quantitatively measured the relative SI of the lesion to adjacent liver parenchyma using region of interests (ROI). Intra-class correlation (ICC) and kappa statistics with quadratic weights (k) analysis, and maximally selected rank statistic were performed. Results: Substantial agreement between fellows (k = 0.719; ICC = 0.705) and almost perfect agreement between attending radiologists (k = 0.853; ICC = 0.849) were found for both qualitative and quantitative assessments of relative SI on delayed HPB imaging. A cut-off ratio to differentiate between hypointense and iso- to hyperintense lesions by ROI was calculated to be 0.90. Conclusion: Inter-observer agreement of liver lesion relative SI on delayed HBP imaging is high and may improve with radiologist experience. A cut-off ratio of relative SI at 0.90 may be useful to quantitatively distinguish hypointense from iso- to hyperintense liver lesions. © 2015, Springer Science+Business Media New York.
Keywords: mri; interreader agreement; eovist; gadoxetic; primovist
Journal Title: Abdominal Radiology
Volume: 41
Issue: 1
ISSN: 2366-004X
Publisher: Springer  
Date Published: 2016-01-01
Start Page: 50
End Page: 55
Language: English
DOI: 10.1007/s00261-015-0609-3
PROVIDER: scopus
PMCID: PMC4740974
PUBMED: 26830611
DOI/URL:
Notes: Article -- Export Date: 2 May 2016 -- Source: Scopus
Altmetric Score
MSK Authors
  1. Junting Zheng
    133 Zheng
  2. Seth Stephen Katz
    16 Katz
  3. Chaya S. Moskowitz
    173 Moskowitz
  4. Scott R Gerst
    42 Gerst
  5. Kinh Gian Do
    116 Do
  6. Sharon Meei Ay Ngu
    1 Ngu