Histologic subtype impacts cancer-specific survival in patients with sarcomatoid-variant renal cell carcinoma treated surgically Journal Article
| Authors: | Nguyen, D. P.; Vilaseca, A.; Vertosick, E. A.; Corradi, R. B.; Touijer, K. A.; Benfante, N. E.; Sjoberg, D. D.; Russo, P. |
| Article Title: | Histologic subtype impacts cancer-specific survival in patients with sarcomatoid-variant renal cell carcinoma treated surgically |
| Abstract: | Purpose: To report survival outcomes of patients treated surgically for sarcomatoid-variant renal cell carcinomas (sRCC) and to assess whether the underlying histologic subtype is an independent predictor of outcome. Methods: One hundred and fifty-one patients underwent surgery at a referral center between 1991 and 2014 and had sRCC in final pathology. Kaplan–Meier curves for metastasis-free survival and cancer-specific survival (CSS) were calculated, and the log-rank test assessed differences between clear cell sRCC and nonclear cell sRCC. Cox regression models were generated to test the prognostic value of histologic subtype. Results: Of 151 patients, 120 (79 %) had clear cell sRCC and 31 (21 %) had nonclear cell sRCC. Ninety-eight (65 %) patients had M0/Mx disease at presentation. Among those M0/Mx patients, metastasis-free survival probabilities were 49 % at 2 years [95 % confidence interval (CI) 38–60] and 39 % at 5 years (95 % CI 28–50), while CSS probabilities were 50 % at 2 years (95 % CI 41–58) and 32 % at 5 years (95 % CI 24–41). There was no significant difference in metastasis-free survival between clear cell and nonclear cell sRCC (p = 0.8). However, patients with nonclear cell sRCC had significantly lower CSS than patients with clear cell sRCC (p = 0.035). In multivariable analyses, nonclear cell sRCC conferred a higher risk of cancer-specific death compared with clear cell sRCC (HR 2.30, 95 % CI 1.38–3.82, p = 0.001). Conclusions: In a cohort of patients treated surgically, the underlying histologic subtype of sRCC had an impact on CSS. These results present valuable information for individual counseling and patient selection in clinical trials. © 2015, Springer-Verlag Berlin Heidelberg. |
| Keywords: | survival; renal cell carcinoma; nephrectomy; sarcomatoid |
| Journal Title: | World Journal of Urology |
| Volume: | 34 |
| Issue: | 4 |
| ISSN: | 0724-4983 |
| Publisher: | Springer |
| Date Published: | 2016-04-01 |
| Start Page: | 539 |
| End Page: | 544 |
| Language: | English |
| DOI: | 10.1007/s00345-015-1644-y |
| PROVIDER: | scopus |
| PUBMED: | 26215750 |
| PMCID: | PMC4962689 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 4 April 2016 -- Source: Scopus |
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