Mutations, kataegis and translocations in B cells: Understanding AID promiscuous activity Journal Article

   

Authors:	Casellas, R.; Basu, U.; Yewdell, W. T.; Chaudhuri, J.; Robbiani, D. F.; Di Noia, J. M.
Article Title:	Mutations, kataegis and translocations in B cells: Understanding AID promiscuous activity
Abstract:	As B cells engage in the immune response, they express activation-induced cytidine deaminase (AID) to initiate the hypermutation and recombination of immunoglobulin genes, which are crucial processes for the efficient recognition and disposal of pathogens. However, AID must be tightly controlled in B cells to minimize off-target mutations, which can drive chromosomal translocations and the development of B cell malignancies, such as lymphomas. Recent genomic and biochemical analyses have begun to unravel the mechanisms of how AID-mediated deamination is targeted outside immunoglobulin genes. Here, we discuss the transcriptional and topological features that are emerging as key drivers of AID promiscuous activity. © 2016 Macmillan Publishers Limited.
Journal Title:	Nature Reviews Immunology
Volume:	16
Issue:	3
ISSN:	1474-1733
Publisher:	Nature Publishing Group
Date Published:	2016-02-22
Start Page:	164
End Page:	176
Language:	English
DOI:	10.1038/nri.2016.2
PROVIDER:	scopus
PUBMED:	26898111
PMCID:	PMC4871114
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-84959499748&partnerID=40&md5=4ca9264bd9b5474aa150729a1405c9b0
Notes:	Review -- Export Date: 4 April 2016 -- Source: Scopus

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