The C. elegans CCAAT-enhancer-binding protein gamma is required for surveillance immunity Journal Article
| Authors: | Reddy, K. C.; Dunbar, T. L.; Nargund, A. M.; Haynes, C. M.; Troemel, E. R. |
| Article Title: | The C. elegans CCAAT-enhancer-binding protein gamma is required for surveillance immunity |
| Abstract: | Pathogens attack host cells by deploying toxins that perturb core host processes. Recent findings from the nematode C. elegans and other metazoans indicate that surveillance or "effector-triggered" pathways monitor functioning of these core processes and mount protective responses when they are perturbed. Despite a growing number of examples of surveillance immunity, the signaling components remain poorly defined. Here, we show that CEBP-2, the C. elegans ortholog of mammalian CCAAT-enhancer-binding protein gamma, is a key player in surveillance immunity. We show that CEBP-2 acts together with the bZIP transcription factor ZIP-2 in the protective response to translational block by P. aeruginosa Exotoxin A as well as perturbations of other processes. CEBP-2 serves to limit pathogen burden, promote survival upon P. aeruginosa infection, and also promote survival upon Exotoxin A exposure. These findings may have broad implications for the mechanisms by which animals sense pathogenic attack and mount protective responses. © 2016 The Authors. |
| Journal Title: | Cell Reports |
| Volume: | 14 |
| Issue: | 7 |
| ISSN: | 2211-1247 |
| Publisher: | Cell Press |
| Date Published: | 2016-02-23 |
| Start Page: | 1581 |
| End Page: | 1589 |
| Language: | English |
| DOI: | 10.1016/j.celrep.2016.01.055 |
| PROVIDER: | scopus |
| PMCID: | PMC4767654 |
| PUBMED: | 26876169 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 4 April 2016 -- Source: Scopus |
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