CCR 20th Anniversary commentary: Immune-related response criteria - Capturing clinical activity in immuno-oncology Journal Article


Authors: Hoos, A.; Wolchok, J. D.; Humphrey, R. W.; Hodi, F. S.
Article Title: CCR 20th Anniversary commentary: Immune-related response criteria - Capturing clinical activity in immuno-oncology
Abstract: To evaluate antitumor responses to chemotherapeutic agents, investigators would typically rely upon Response Evaluation Criteria in Solid Tumors (RECIST) or modified WHO criteria, which do not comprehensively capture responses with immunotherapeutic agents. In the December 1, 2009, issue of Clinical Cancer Research, Wolchok and colleagues reported their development of novel criteria, designated "Immune-related Response Criteria" (irRC), designed to better capture the response patterns observed with immunotherapies. Broad use of the irRC since then has allowed for a more comprehensive evaluation of immunotherapies in clinical trials, indicating that their concepts can be used in conjunction with either RECIST or WHO, and has shown irRC to be a powerful tool for improved clinical investigation. ©2015 AACR.
Keywords: melanoma; immunotherapy; standards; procedures; humans; human; male; female
Journal Title: Clinical Cancer Research
Volume: 21
Issue: 22
ISSN: 1078-0432
Publisher: American Association for Cancer Research  
Date Published: 2015-11-15
Start Page: 4989
End Page: 4991
Language: English
DOI: 10.1158/1078-0432.ccr-14-3128
PUBMED: 26567357
PROVIDER: scopus
DOI/URL:
Notes: Note -- Export Date: 3 March 2016 -- Source: Scopus
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MSK Authors
  1. Jedd D Wolchok
    656 Wolchok