Two-dimensional speckle tracking echocardiography detects subclinical left ventricular systolic dysfunction among adult survivors of childhood, adolescent, and young adult cancer Journal Article
| Authors: | Yu, A. F.; Raikhelkar, J.; Zabor, E. C.; Tonorezos, E. S.; Moskowitz, C. S.; Adsuar, R.; Mara, E.; Huie, K.; Oeffinger, K. C.; Steingart, R. M.; Liu, J. E. |
| Article Title: | Two-dimensional speckle tracking echocardiography detects subclinical left ventricular systolic dysfunction among adult survivors of childhood, adolescent, and young adult cancer |
| Abstract: | Two-dimensional speckle tracking echocardiography (2DSTE) provides a sensitive measure of left ventricular (LV) systolic function and may aid in the diagnosis of cardiotoxicity. 2DSTE was performed in a cross-sectional study of 134 patients (mean age: 31.4 ± 8.8 years; 55% male; mean time since diagnosis: 15.4 ± 9.4 years) previously treated with anthracyclines (mean cumulative dose: 320 ± 124 mg/m2), with (n = 52) or without (n = 82) mediastinal radiotherapy. The prevalence of LV systolic dysfunction, defined as fractional shortening < 27%, LV ejection fraction (LVEF) < 55%, and global longitudinal strain (GLS) ≤ 16%, was 5.2%, 6.0%, and 23.1%, respectively. Abnormal GLS was observed in 24 (18%) patients despite a normal LVEF. Indices of LV systolic function were similar regardless of anthracycline dose. However, GLS was worse (18.0 versus 19.0, p = 0.003) and prevalence of abnormal GLS was higher (36.5% versus 14.6%, p = 0.004) in patients treated with mediastinal radiotherapy. Mediastinal radiotherapy was associated with reduced GLS (p = 0.040) after adjusting for sex, age, and cumulative anthracycline dose. In adult survivors of childhood, adolescent, and young adult cancer, 2DSTE frequently detects LV systolic dysfunction despite a normal LVEF and may be useful for the long-term cardiac surveillance of adult cancer survivors. © 2016 Anthony F. Yu et al. |
| Journal Title: | Biomed Research International |
| Volume: | 2016 |
| ISSN: | 2314-6133 |
| Publisher: | Hindawi Publishing Corporation |
| Date Published: | 2016-01-01 |
| Start Page: | 9363951 |
| Language: | English |
| DOI: | 10.1155/2016/9363951 |
| PROVIDER: | scopus |
| PMCID: | PMC4749762 |
| PUBMED: | 26942202 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 March 2016 -- Source: Scopus |
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