Two-dimensional speckle tracking echocardiography detects subclinical left ventricular systolic dysfunction among adult survivors of childhood, adolescent, and young adult cancer Journal Article


Authors: Yu, A. F.; Raikhelkar, J.; Zabor, E. C.; Tonorezos, E. S.; Moskowitz, C. S.; Adsuar, R.; Mara, E.; Huie, K.; Oeffinger, K. C.; Steingart, R. M.; Liu, J. E.
Article Title: Two-dimensional speckle tracking echocardiography detects subclinical left ventricular systolic dysfunction among adult survivors of childhood, adolescent, and young adult cancer
Abstract: Two-dimensional speckle tracking echocardiography (2DSTE) provides a sensitive measure of left ventricular (LV) systolic function and may aid in the diagnosis of cardiotoxicity. 2DSTE was performed in a cross-sectional study of 134 patients (mean age: 31.4 ± 8.8 years; 55% male; mean time since diagnosis: 15.4 ± 9.4 years) previously treated with anthracyclines (mean cumulative dose: 320 ± 124 mg/m2), with (n = 52) or without (n = 82) mediastinal radiotherapy. The prevalence of LV systolic dysfunction, defined as fractional shortening < 27%, LV ejection fraction (LVEF) < 55%, and global longitudinal strain (GLS) ≤ 16%, was 5.2%, 6.0%, and 23.1%, respectively. Abnormal GLS was observed in 24 (18%) patients despite a normal LVEF. Indices of LV systolic function were similar regardless of anthracycline dose. However, GLS was worse (18.0 versus 19.0, p = 0.003) and prevalence of abnormal GLS was higher (36.5% versus 14.6%, p = 0.004) in patients treated with mediastinal radiotherapy. Mediastinal radiotherapy was associated with reduced GLS (p = 0.040) after adjusting for sex, age, and cumulative anthracycline dose. In adult survivors of childhood, adolescent, and young adult cancer, 2DSTE frequently detects LV systolic dysfunction despite a normal LVEF and may be useful for the long-term cardiac surveillance of adult cancer survivors. © 2016 Anthony F. Yu et al.
Journal Title: Biomed Research International
Volume: 2016
ISSN: 2314-6133
Publisher: Hindawi Publishing Corporation  
Date Published: 2016-01-01
Start Page: 9363951
Language: English
DOI: 10.1155/2016/9363951
PROVIDER: scopus
PMCID: PMC4749762
PUBMED: 26942202
DOI/URL:
Notes: Article -- Export Date: 3 March 2016 -- Source: Scopus
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MSK Authors
  1. Jennifer Liu
    63 Liu
  2. Richard M Steingart
    140 Steingart
  3. Chaya S. Moskowitz
    213 Moskowitz
  4. Kevin Oeffinger
    294 Oeffinger
  5. Emily Craig Zabor
    171 Zabor
  6. Roberto Adsuar
    10 Adsuar
  7. Anthony Yu
    62 Yu
  8. Elton   Mara
    3 Mara