Two-dimensional speckle tracking echocardiography detects subclinical left ventricular systolic dysfunction among adult survivors of childhood, adolescent, and young adult cancer Journal Article


Authors: Yu, A. F.; Raikhelkar, J.; Zabor, E. C.; Tonorezos, E. S.; Moskowitz, C. S.; Adsuar, R.; Mara, E.; Huie, K.; Oeffinger, K. C.; Steingart, R. M.; Liu, J. E.
Article Title: Two-dimensional speckle tracking echocardiography detects subclinical left ventricular systolic dysfunction among adult survivors of childhood, adolescent, and young adult cancer
Abstract: Two-dimensional speckle tracking echocardiography (2DSTE) provides a sensitive measure of left ventricular (LV) systolic function and may aid in the diagnosis of cardiotoxicity. 2DSTE was performed in a cross-sectional study of 134 patients (mean age: 31.4 ± 8.8 years; 55% male; mean time since diagnosis: 15.4 ± 9.4 years) previously treated with anthracyclines (mean cumulative dose: 320 ± 124 mg/m2), with (n = 52) or without (n = 82) mediastinal radiotherapy. The prevalence of LV systolic dysfunction, defined as fractional shortening < 27%, LV ejection fraction (LVEF) < 55%, and global longitudinal strain (GLS) ≤ 16%, was 5.2%, 6.0%, and 23.1%, respectively. Abnormal GLS was observed in 24 (18%) patients despite a normal LVEF. Indices of LV systolic function were similar regardless of anthracycline dose. However, GLS was worse (18.0 versus 19.0, p = 0.003) and prevalence of abnormal GLS was higher (36.5% versus 14.6%, p = 0.004) in patients treated with mediastinal radiotherapy. Mediastinal radiotherapy was associated with reduced GLS (p = 0.040) after adjusting for sex, age, and cumulative anthracycline dose. In adult survivors of childhood, adolescent, and young adult cancer, 2DSTE frequently detects LV systolic dysfunction despite a normal LVEF and may be useful for the long-term cardiac surveillance of adult cancer survivors. © 2016 Anthony F. Yu et al.
Journal Title: Biomed Research International
Volume: 2016
ISSN: 2314-6133
Publisher: Hindawi Publishing Corporation  
Date Published: 2016-01-01
Start Page: 9363951
Language: English
DOI: 10.1155/2016/9363951
PROVIDER: scopus
PMCID: PMC4749762
PUBMED: 26942202
DOI/URL:
Notes: Article -- Export Date: 3 March 2016 -- Source: Scopus
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MSK Authors
  1. Jennifer Liu
    39 Liu
  2. Richard M Steingart
    116 Steingart
  3. Chaya S. Moskowitz
    173 Moskowitz
  4. Kevin Oeffinger
    255 Oeffinger
  5. Emily Craig Zabor
    131 Zabor
  6. Roberto Adsuar
    8 Adsuar
  7. Anthony Yu
    37 Yu
  8. Elton   Mara
    3 Mara