Stem cell transplantation in adults with acute myelogenous leukemia, normal cytogenetics, and the FLT3-ITD mutation Journal Article

   

Authors:	Berman, E.; Maloy, M.; Devlin, S.; Jhanwar, S.; Papadopoulos, E.; Jakubowski, A.
Article Title:	Stem cell transplantation in adults with acute myelogenous leukemia, normal cytogenetics, and the FLT3-ITD mutation
Abstract:	Following chemotherapy, patients with acute myelogenous leukemia (AML), normal cytogenetics, and the FLT3-ITD mutation have shorter survival compared to wild type (WT) patients. To determine the role of stem cell transplantation (SCT), we performed a retrospective review of adult patients with AML who underwent SET at our center between January 1, 2007 and December 31, 2011. Of the 200 patients transplanted, 79 patients (40%) had normal cytogenetics; of these, 17(22%) had the FLT3-ITD mutation, 35 were WT (44%), and 27 (34%) did not have FLT3 testing performed. Clinical characteristics were similar in each group. At four years, overall survival (OS) between FLT3 positive and WT groups was similar: 0.54 (95% CI 0.29-0.75) versus 0.73 (95% CI 0.53-0.99), p = 0.18. Relapse rates were also similar, 0.09 (95% CI 0.02-0.21) versus 0.12 (95% CI: 0.02-0.32); p = 0.67. We conclude that SCT can abrogate the poor prognosis in FLT3-ITD positive patients. (C) 2015 Elsevier Ltd. All rights reserved.
Keywords:	stem cell transplant; blood; engraftment; impact; malignancies; acute myeloid-leukemia; trials; allogeneic transplantation; aml; hematologic; 1st remission; flt3-itd; flt3/itd
Journal Title:	Leukemia Research
Volume:	40
ISSN:	0145-2126
Publisher:	Elsevier Ltd
Date Published:	2016-01-01
Start Page:	33
End Page:	37
Language:	English
ACCESSION:	WOS:000367237000006
DOI:	10.1016/j.leukres.2015.11.010
PROVIDER:	wos
PUBMED:	26692109
PMCID:	PMC5053396
Notes:	Article -- Source: Wos

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