Early-stage nodular lymphocyte-predominant Hodgkin lymphoma: The impact of radiotherapy on overall survival Journal Article


Authors: Parikh, R. R.; Grossbard, M. L.; Harrison, L. B.; Yahalom, J.
Article Title: Early-stage nodular lymphocyte-predominant Hodgkin lymphoma: The impact of radiotherapy on overall survival
Abstract: The purpose of this study was to use the National Cancer Database to examine the association between radiation therapy (RT) and overall survival (OS) in early-stage nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) using standard and propensity score (PS)-adjusted Cox proportional hazards models. From 1998-2011, 1915 patients with stage I/II NLPHL were studied, with a median follow-up of 6.6 years (median age = 44). Of the cohort, 1224(64%) received RT (alone or with chemotherapy) to a median dose of 30.6 Gy. Patients were more likely to receive RT if male, younger age, lower stage, no "B"-symptoms, favorably insured, and treatment at comprehensive centers (all p < 0.05). Patients administered RT had an improved 5-year OS (HR = 0.62; 95%CI, 0.43-0.89, p = 0.01). After PS-matching (n = 868) based on all known co-variates, RT use trended towards improved OS (HR = 0.49; 95%CI, 0.23-1.05, p = 0.06). This study represents one of the largest prospective datasets examining the role of RT for stage I/II NLPHL and inclusion of RT may be considered. © 2015 Informa UK, Ltd.
Keywords: overall survival; radiotherapy; lymphocyte-predominant hodgkin lymphoma; national cancer database
Journal Title: Leukemia and Lymphoma
Volume: 57
Issue: 2
ISSN: 1042-8194
Publisher: Taylor & Francis Group  
Date Published: 2016-01-01
Start Page: 320
End Page: 327
Language: English
DOI: 10.3109/10428194.2015.1065978
PROVIDER: scopus
PUBMED: 26110882
PMCID: PMC5593757
DOI/URL:
Notes: Article -- Export Date: 3 February 2016 -- Source: Scopus
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  1. Joachim Yahalom
    461 Yahalom