Genetic diversity of pancreatic ductal adenocarcinoma and opportunities for precision medicine Journal Article
| Authors: | Knudsen, E. S.; O'Reilly, E. M.; Brody, J. R.; Witkiewicz, A. K. |
| Article Title: | Genetic diversity of pancreatic ductal adenocarcinoma and opportunities for precision medicine |
| Abstract: | Patients with pancreatic ductal adenocarcinoma (PDA) have a poor prognosis despite new treatments; approximately 7% survive for 5 years. Although there have been advances in systemic, primarily cytotoxic, therapies, it has been a challenge to treat patients with PDA using targeted therapies. Sequence analyses have provided a wealth of information about the genetic features of PDA and have identified potential therapeutic targets. Preclinical and early-phase clinical studies have found specific pathways could be rationally targeted; it might also be possible to take advantage of the genetic diversity of PDAs to develop therapeutic agents. The genetic diversity and instability of PDA cells have long been thought of as obstacles to treatment, but are now considered exploitable features. We review the latest findings in pancreatic cancer genetics and the promise of targeted approaches in PDA therapy. © 2016 AGA Institute. |
| Keywords: | signal transduction; mitogen activated protein kinase; gene mutation; clinical feature; fluorouracil; nonhuman; systemic therapy; drug targeting; capecitabine; gemcitabine; pancreas cancer; antineoplastic agent; genetic analysis; dna damage; gene targeting; dna repair; genetic variability; notch receptor; monoclonal antibody; oncogene; folinic acid; microsatellite instability; pancreas adenocarcinoma; chromosomal instability; cyclin dependent kinase inhibitor 2a; kras; oxaliplatin; k ras protein; b raf kinase; chromatin assembly and disassembly; myc; personalized medicine; phosphatidylinositol 3 kinase inhibitor; cyclin dependent kinase 6; notch; protein kinase b inhibitor; clinical trial (topic); molecularly targeted therapy; phase 2 clinical trial (topic); phase 3 clinical trial (topic); phase 1 clinical trial (topic); selumetinib; next generation sequencing; wnt signaling pathway; trametinib; smad4; human; priority journal; article; binimetinib; tarextumab |
| Journal Title: | Gastroenterology |
| Volume: | 150 |
| Issue: | 1 |
| ISSN: | 0016-5085 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2016-01-01 |
| Start Page: | 48 |
| End Page: | 63 |
| Language: | English |
| DOI: | 10.1053/j.gastro.2015.08.056 |
| PROVIDER: | scopus |
| PUBMED: | 26385075 |
| PMCID: | PMC5010785 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 February 2016 -- Source: Scopus |
