First-in-human multicenter phase i study of BMS-936561 (MDX-1203), an antibody-drug conjugate targeting CD70 Journal Article

Authors: Owonikoko, T. K.; Hussain, A.; Stadler, W. M.; Smith, D. C.; Kluger, H.; Molina, A. M.; Gulati, P.; Shah, A.; Ahlers, C. M.; Cardarelli, P. M.; Cohen, L. J.
Article Title: First-in-human multicenter phase i study of BMS-936561 (MDX-1203), an antibody-drug conjugate targeting CD70
Abstract: Purpose: The study evaluated the safety, tolerability, and pharmacokinetics of BMS-936561, a fully human monoclonal antibody-drug conjugate targeting CD70 cell-surface protein. Methods: Eligible patients had ECOG performance status 0-2 and received ≤3 prior chemotherapy regimens. An initial accelerated titration design enrolling one patient per dose level was followed by 3 + 3 dose escalation with the first observation of a grade ≥2 adverse event (AE). We tested escalating doses of BMS-936561 (0.5, 1, 2, 4, 8, 15 mg/kg) administered every 21 days in a 42 day cycle for a maximum of 17 cycles. Pharmacokinetic samples were collected in cycle 1. Results: A total of 26 patients enrolled; 16 and 10 for the escalation and expansion cohorts, respectively. Median age was 63 years (48-74); 18 males and 25 Caucasians. There was no defined MTD per protocol, but a DLT of grade 3 hypersensitivity was recorded in 2 of 16 (13 %) subjects at the highest dose of 15 mg/kg. The most frequent AEs were: fatigue (85 %), nausea (54 %), and decreased appetite (39 %). Delayed toxicities (facial edema and pleural/pericardial effusions) occurred in 6 of 16 (38 %) subjects at the 15 mg/kg dose. PK analysis showed a dose-proportional increase in active drug levels with increasing doses. There was disease stabilization in 18 of 26 patients (69 %) without correlation with received dose. Conclusions: BMS-936561 is well tolerated over a wide range of doses in patients with advanced ccRCC and B-NHL. The 8 mg/kg dose was the highest best tolerated dose and the recommended dose for future studies. © 2015 Springer-Verlag Berlin Heidelberg.
Keywords: phase; pharmacokinetic; antibody-drug conjugate; cd70; bms-936561
Journal Title: Cancer Chemotherapy and Pharmacology
Volume: 77
Issue: 1
ISSN: 0344-5704
Publisher: Springer  
Date Published: 2016-01-01
Start Page: 155
End Page: 162
Language: English
DOI: 10.1007/s00280-015-2909-2
PROVIDER: scopus
PUBMED: 26576779
Notes: Article -- Export Date: 3 February 2016 -- Source: Scopus
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MSK Authors
  1. Ana Maria Luisa Molina
    50 Molina