Clinical Assessment of 2D/3D registration accuracy in 4 major anatomic sites using on-board 2D kilovoltage images for 6D patient setup Journal Article
| Authors: | Li, G.; Yang, T. J.; Furtado, H.; Birkfellner, W.; Ballangrud, A.; Powell, S. N.; Mechalakos, J. |
| Article Title: | Clinical Assessment of 2D/3D registration accuracy in 4 major anatomic sites using on-board 2D kilovoltage images for 6D patient setup |
| Abstract: | To provide a comprehensive assessment of patient setup accuracy in 6 degrees of freedom (DOFs) using 2-dimensional/3-dimensional (2D/3D) image registration with on-board 2-dimensional kilovoltage (OB-2DkV) radiographic images, we evaluated cranial, head and neck (HN), and thoracic and abdominal sites under clinical conditions. A fast 2D/3D image registration method using graphics processing unit GPU was modified for registration between OB-2DkV and 3D simulation computed tomography (simCT) images, with 3D/3D registration as the gold standard for 6DOF alignment. In 2D/3D registration, body roll rotation was obtained solely by matching orthogonal OB-2DkV images with a series of digitally reconstructed radiographs (DRRs) from simCT with a small rotational increment along the gantry rotation axis. The window/level adjustments for optimal visualization of the bone in OB-2DkV and DRRs were performed prior to registration. Ideal patient alignment at the isocenter was calculated and used as an initial registration position. In 3D/3D registration, cone-beam CT (CBCT) was aligned to simCT on bony structures using a bone density filter in 6DOF. Included in this retrospective study were 37 patients treated in 55 fractions with frameless stereotactic radiosurgery or stereotactic body radiotherapy for cranial and paraspinal cancer. A cranial phantom was used to serve as a control. In all cases, CBCT images were acquired for patient setup with subsequent OB-2DkV verification. It was found that the accuracy of the 2D/3D registration was 0.0 ± 0.5 mm and 0.1° ± 0.4° in phantom. In patient, it is site dependent due to deformation of the anatomy: 0.2 ± 1.6 mm and −0.4° ± 1.2° on average for each dimension for the cranial site, 0.7 ± 1.6 mm and 0.3° ± 1.3° for HN, 0.7 ± 2.0 mm and −0.7° ± 1.1° for the thorax, and 1.1 ± 2.6 mm and −0.5° ± 1.9° for the abdomen. Anatomical deformation and presence of soft tissue in 2D/3D registration affect the consistency with 3D/3D registration in 6DOF: the discrepancy increases in superior to inferior direction. © 2014, © The Author(s) 2014. |
| Keywords: | image registration; image-guided radiotherapy; patient setup; rotational correction |
| Journal Title: | Technology in Cancer Research & Treatment |
| Volume: | 14 |
| Issue: | 3 |
| ISSN: | 1533-0346 |
| Publisher: | Sage Publications, Inc. |
| Date Published: | 2015-06-01 |
| Start Page: | 305 |
| End Page: | 314 |
| Language: | English |
| DOI: | 10.1177/1533034614547454 |
| PROVIDER: | scopus |
| PMCID: | PMC4544868 |
| PUBMED: | 25223323 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 February 2016 -- Source: Scopus |
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