A focal lesion in the falx cerebri: Harbinger of classic stage 4 neuroblastoma in an infant cured despite residual disease after minimal therapy Journal Article
| Authors: | Kushner, B. H.; Kramer, K.; Modak, S.; Akhurst, T. J.; Cheung, N. K. V. |
| Article Title: | A focal lesion in the falx cerebri: Harbinger of classic stage 4 neuroblastoma in an infant cured despite residual disease after minimal therapy |
| Abstract: | An asymptomatic 11 weeks old received no treatment after he was classified as having a suspected atypical form of MYCN-nonamplified hyperdiploid stage 4S neuroblastoma (NB), with masses in an adrenal gland, subcutaneous tissues, and the falx cerebri. Within 2 months, however, disease progressed in dura and bone marrow. Two cycles of low-dose chemotherapy achieved a partial response; treatment was discontinued. Complete remission was documented 24 weeks post-cycle 2, and has continued >6 years. The falx cerebri probably does not represent an atypical site for stage 4S NB, but stage 4 NB with favorable biology is sometimes curable with minimal therapy. © 2009 Wiley-Liss, Inc. |
| Keywords: | treatment response; disease-free survival; genetics; histopathology; case report; doxorubicin; disease free survival; cancer staging; nuclear magnetic resonance imaging; antineoplastic agent; neoplasm staging; carboplatin; metastasis; bone marrow; skin neoplasms; etoposide; antineoplastic combined chemotherapy protocols; cyclophosphamide; pathology; skin tumor; diagnostic agent; radioactive iodine; iodine radioisotopes; infant; meningeal neoplasms; neuroblastoma; minimal residual disease; neoplasm, residual; scintiscanning; (3 iodobenzyl)guanidine; (3 iodobenzyl)guanidine i 123; 3-iodobenzylguanidine; remission; remission induction; meningioma; femur; aneuploidy; falx cerebri; mibg; minimal therapy; adrenal tumor; femur tumor; dura mater; adrenal gland neoplasms |
| Journal Title: | Pediatric Blood and Cancer |
| Volume: | 53 |
| Issue: | 7 |
| ISSN: | 1545-5009 |
| Publisher: | Wiley Periodicals, Inc |
| Date Published: | 2009-12-15 |
| Start Page: | 1340 |
| End Page: | 1342 |
| Language: | English |
| DOI: | 10.1002/pbc.22243 |
| PUBMED: | 19711437 |
| PROVIDER: | scopus |
| PMCID: | PMC4079037 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 30 November 2010" - "CODEN: PBCEA" - "Source: Scopus" |
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