Molecular genetics of acute promyelocytic leukemia: A rationale for "transcription therapy" for cancer Conference Paper
| Author: | Pandolfi, P. P. |
| Editors: | Ikeda, Y.; Hata, J.; Koyasu, S.; Kawakami, Y.; Hattori, Y. |
| Title: | Molecular genetics of acute promyelocytic leukemia: A rationale for "transcription therapy" for cancer |
| Conference Title: | 5th Keio University International Symposium for Life Sciences and Medicine on Cell Therapy |
| Abstract: | The last few years have been crucial for the elucidation of the molecular mechanisms underlying the pathogenesis of human leukemia [1]. In particular, more than 80% of myeloid leukemias have been attributed to, or associated with, one or more specific molecular lesions. In the vast majority of cases these molecular events are chromosomal translocations that rearrange the regulatory and coding regions of a variety of genes which encode transcription factors. These proteins can interfere with the normal transduction, at the transcription level, of pivotal cellular processes such as growth, differentiation, and survival. The identification of these lesions renders it possible to reclassify myeloid leukemias according to new "molecular" criteria, and to develop new diagnostic and prognostic tools. Furthermore, the understanding of the aberrant transcriptional mechanisms underlying leukemia pathogenesis allows the development of new therapeutic approaches. In particular, the recent elucidation of the molecular mechanisms underlying the pathogenesis of acute promyelocytic leukemia has allowed us to propose and exploit what we regard as a new concept for the treatment of cancer, which we refer to as "transcription therapy". |
| Keywords: | transcription factors; chromatin; fusion proteins; differentiation; translocation; domain; acute myeloid-leukemia; structure; plzf; dna-binding; hdac inhibitors; pml-rar-alpha; retinoic acid receptors; cancer; transcription therapy; histone deacetylase complex |
| Journal Title | Keio University International Symposia for Life Sciences and Medicine |
| Volume: | 5 |
| Conference Dates: | 1999 Jan 21-23 |
| Conference Location: | Tokyo, Japan |
| ISBN: | 978-4-431-68508-1 |
| Publisher: | Springer Verlag |
| Location: | Tokyo |
| Date Published: | 2000-01-01 |
| Start Page: | 123 |
| End Page: | 132 |
| Language: | English |
| ACCESSION: | WOS:000088114100011 |
| PROVIDER: | wos |
| DOI: | 10.1007/978-4-431-68506-7_11 |
| Notes: | Proceedings Paper -- Special Topic Symposium: Cell Therapy -- KEIO UNIV, TOKYO, JAPAN -- Keio Univ Med Sci Fund -- 37-3, HONGO 3-CHOME BONKYO-KU, TOKYO, 113, JAPAN -- Source: Wos |
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