Targeted radioimmunotherapy for leptomeningeal cancer using (131)I-3F8 Journal Article


Authors: Kramer, K.; Cheung, N. K. V.; Humm, J. L.; Dantis, E.; Finn, R.; Yeh, S. J.; Antunes, N. L.; Dunkel, I. J.; Souweidane, M.; Larson, S. M.
Article Title: Targeted radioimmunotherapy for leptomeningeal cancer using (131)I-3F8
Abstract: Background. Intrathecal antibody-based targeted therapies may have clinical potential for patients with leptomeningeal (LM) cancer. Procedure. Five patients with GD2-positive LM tumors were injected with 1-2 mCi intra-Ommaya 131I-3F8, a murine IgG3 antibody specific for GD2. Serial cerebrospinal fluid (CSF) and serum samples and SPECT imagings (4, 24, and 48 hr) were performed to predict radiation doses to the tumor and normal brain and blood prior to the administration of larger therapeutic doses. Results. Side effects included self-limited fever, headache, and vomiting. Focal 131I-3F8 uptake consistent with tumors was seen along the craniospinal axis in four patients. Calculated radiation dose to the CSF was 14.9-56 cGy/mCi and to blood and other organs outside the CNS less than 2 cGy/mCi. Conclusions. Intraventricular 131I-3F8 successfully detected LM disease and resulted in a large favorable CSF/blood ratio. Intraventricular 131I-3F8 may have clinical utility in the diagnosis and radioimmunotherapy of GD2-positive LM cancers. (C) 2000 Wiley-Liss, Inc.
Keywords: adult; child; clinical article; child, preschool; middle aged; conference paper; radiation dose; vomiting; monoclonal antibody; fever; antibodies, monoclonal; immunoglobulin g; iodine 131; iodine radioisotopes; infant; meningeal neoplasms; brain cancer; headache; antibodies; radioimmunotherapy; single photon emission computer tomography; immunoglobulins; ganglioside; humans; human; priority journal; 131i-3f8; leptomeningeal cancer
Journal Title: Medical and Pediatric Oncology
Volume: 35
Issue: 6
ISSN: 0098-1532
Publisher: Wiley Liss  
Date Published: 2000-12-01
Start Page: 716
End Page: 718
Language: English
DOI: 10.1002/1096-911x(20001201)35:6<716::aid-mpo51>3.0.co;2-0
PUBMED: 11107154
PROVIDER: scopus
DOI/URL:
Notes: Export Date: 18 November 2015 -- Source: Scopus
Altmetric
Citation Impact
MSK Authors
  1. Samuel D J Yeh
    82 Yeh
  2. Nai-Kong Cheung
    530 Cheung
  3. Ira J Dunkel
    282 Dunkel
  4. Kim Kramer
    187 Kramer
  5. Nuno L Antunes
    22 Antunes
  6. Ronald D Finn
    278 Finn
  7. John Laurence Humm
    365 Humm
  8. Steven M Larson
    877 Larson
  9. Ester C Dantis
    5 Dantis