Cysteine cathepsin proteases: Regulators of cancer progression and therapeutic response Journal Article
| Authors: | Olson, O. C.; Joyce, J. A. |
| Article Title: | Cysteine cathepsin proteases: Regulators of cancer progression and therapeutic response |
| Abstract: | Cysteine cathepsin protease activity is frequently dysregulated in the context of neoplastic transformation. Increased activity and aberrant localization of proteases within the tumour microenvironment have a potent role in driving cancer progression, proliferation, invasion and metastasis. Recent studies have also uncovered functions for cathepsins in the suppression of the response to therapeutic intervention in various malignancies. However, cathepsins can be either tumour promoting or tumour suppressive depending on the context, which emphasizes the importance of rigorous in vivo analyses to ascertain function. Here, we review the basic research and clinical findings that underlie the roles of cathepsins in cancer, and provide a roadmap for the rational integration of cathepsin-targeting agents into clinical treatment. © 2015 Macmillan Publishers Limited. All rights reserved. |
| Keywords: | treatment response; review; cancer growth; nonhuman; cell death; protein degradation; in vivo study; antineoplastic activity; enzyme activity; angiogenesis; cancer resistance; cancer cell; cathepsin; cell junction; cell invasion; membrane permeability; predictive value; lysosome membrane; tumor microenvironment; cysteine proteinase; cancer prognosis; human; priority journal |
| Journal Title: | Nature Reviews Cancer |
| Volume: | 15 |
| Issue: | 12 |
| ISSN: | 1474-175X |
| Publisher: | Nature Publishing Group |
| Date Published: | 2015-12-01 |
| Start Page: | 712 |
| End Page: | 729 |
| Language: | English |
| DOI: | 10.1038/nrc4027 |
| PROVIDER: | scopus |
| PUBMED: | 26597527 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 7 January 2016 -- 712 -- Source: Scopus |
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