Emerging mechanisms of resistance to androgen receptor inhibitors in prostate cancer Journal Article

   


Authors: Watson, P. A.; Arora, V. K.; Sawyers, C. L.
Article Title: Emerging mechanisms of resistance to androgen receptor inhibitors in prostate cancer
Abstract: During the past 10 years, preclinical studies implicating sustained androgen receptor (AR) signalling as the primary driver of castration-resistant prostate cancer (CRPC) have led to the development of novel agents targeting the AR pathway that are now in widespread clinical use. These drugs prolong the survival of patients with late-stage prostate cancer but are not curative. In this Review, we highlight emerging mechanisms of acquired resistance to these contemporary therapies, which fall into the three broad categories of restored AR signalling, AR bypass signalling and complete AR independence. This diverse range of resistance mechanisms presents new challenges for long-term disease control, which may be addressable through early use of combination therapies guided by recent insights from genomic landscape studies of CRPC. © 2015 Macmillan Publishers Limited. All rights reserved.
Keywords: cancer survival; unclassified drug; mutation; androgen; review; cancer resistance; goserelin; leuprorelin; alternative rna splicing; genomics; androgen receptor; antiandrogen; bicalutamide; flutamide; nilutamide; disease control; degarelix; triptorelin; testosterone; ligand binding; synthesis; androstanolone; castration resistant prostate cancer; abiraterone; histrelin; enzalutamide; antiandrogen therapy; galeterone; odm 201; human; male; priority journal; apalutamide
Journal Title: Nature Reviews Cancer
Volume: 15
Issue: 12
ISSN: 1474-175X
Publisher: Nature Publishing Group  
Date Published: 2015-12-01
Start Page: 701
End Page: 711
Language: English
DOI: 10.1038/nrc4016
PROVIDER: scopus
PUBMED: 26563462
PMCID: PMC4771416
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84948717393&partnerID=40&md5=4c6f07c3829a83c52941d93e8d50844f
Notes: Review -- Export Date: 7 January 2016 -- 701 -- Source: Scopus
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MSK Authors
  1. Charles L Sawyers
    225 Sawyers
  2. Philip A Watson
    26 Watson
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