Successful treatment of esophageal cancer with airway invasion with induction chemotherapy and concurrent chemoradiotherapy Journal Article
| Authors: | Ku, G. Y.; Goodman, K. A.; Rusch, V. W.; Ilson, D. H. |
| Article Title: | Successful treatment of esophageal cancer with airway invasion with induction chemotherapy and concurrent chemoradiotherapy |
| Abstract: | Esophageal cancer with airway invasion with or without fistula presents a challenging therapeutic dilemma with no standard therapy. Recent studies in Japan have focused on the use of definitive chemoradiotherapy. However, this approach is associated withsignificant treatment-related morbidity and mortality. We present a case report of a patient with thoracic esophageal squamous cell carcinoma with bronchial invasion who was treated to a clinical complete response with induction chemotherapy followed by consolidation with concurrent chemoradiotherapy. The patient also underwent restaging with a positron emission tomography scan after induction chemotherapy. Such a staged approach may reduce the morbidity of upfront radiation. The use of an interim positron emission tomography scan may also identify early treatment failure. © 2009 by the International Association for the Study of Lung Cancer. |
| Keywords: | immunohistochemistry; human tissue; treatment outcome; treatment response; aged; case report; squamous cell carcinoma; carcinoma, squamous cell; cisplatin; multimodality cancer therapy; adjuvant therapy; radiation dose; chemotherapy, adjuvant; combined modality therapy; radiotherapy, adjuvant; cancer staging; positron emission tomography; follow up; follow-up studies; neoplasm staging; cytology; metastasis; computer assisted tomography; morbidity; pathology; biopsy; risk assessment; irinotecan; cancer invasion; dysphagia; biopsy, needle; adjuvant chemotherapy; needle biopsy; positron-emission tomography; scintiscanning; neoplasm invasiveness; endoscopy; drug tolerance; deglutition disorders; esophagus tumor; esophageal neoplasms; chemoradiotherapy; esophageal cancer; induction chemotherapy; airway; esophageal squamous cell carcinoma; bronchus tumor; endoscopic echography; bronchial neoplasms; endosonography |
| Journal Title: | Journal of Thoracic Oncology |
| Volume: | 4 |
| Issue: | 3 |
| ISSN: | 1556-0864 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2009-03-01 |
| Start Page: | 432 |
| End Page: | 434 |
| Language: | English |
| DOI: | 10.1097/JTO.0b013e3181989efa |
| PUBMED: | 19247092 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 30 November 2010" - "Source: Scopus" |
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