Humanized affinity-matured monoclonal antibody 8H9 has potent antitumor activity and binds to FG loop of tumor antigen B7-H3 Journal Article

   


Authors: Ahmed, M.; Cheng, M.; Zhao, Q.; Goldgur, Y.; Cheal, S. M.; Guo, H. F. ; Larson, S. M.; Cheung, N. K. V.
Article Title: Humanized affinity-matured monoclonal antibody 8H9 has potent antitumor activity and binds to FG loop of tumor antigen B7-H3
Abstract: Background: B7-H3 is an immune inhibitory ligand and an antigen on many solid tumors. Results: Antibody 8H9 was humanized and affinity-matured, and its epitope was mapped to the FG loop of B7-H3. Conclusion: hu8H9 antibodies had potent antitumor activity and may modulate immune inhibitory properties of B7-H3. Significance: Antibodies were developed to target solid tumors and affect immune checkpoint blockade. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.
Keywords: controlled study; protein expression; unclassified drug; human cell; nonhuman; drug targeting; antineoplastic agent; binding affinity; animal cell; mouse; animal tissue; animal experiment; animal model; antineoplastic activity; drug potency; drug structure; in vitro study; immunoreactivity; tumor antigen; monoclonal antibodies; monoclonal antibody; antigens; immunoglobulin g; drug distribution; neuroblastoma; tumors; antibodies; drug binding; single chain fragment variable antibody; solid tumors; cell mediated cytotoxicity; b7 h3 antigen; epitopes; antibody combining site; monoclonal antibody 8h9; human; female; priority journal; article; ec50; anti-tumor activities
Journal Title: Journal of Biological Chemistry
Volume: 290
Issue: 50
ISSN: 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology  
Date Published: 2015-12-11
Start Page: 30018
End Page: 30029
Language: English
DOI: 10.1074/jbc.M115.679852
PROVIDER: scopus
PMCID: PMC4705981
PUBMED: 26487718
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84949639635&partnerID=40&md5=34bb40965be8e75c7b9739c88d79e466
Notes: Article -- Export Date: 7 January 2016 -- 30018 -- Source: Scopus
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MSK Authors
  1. Nai-Kong Cheung
    650 Cheung
  2. Mahiuddin Ahmed
    14 Ahmed
  3. Yehuda Goldgur
    42 Goldgur
  4. Ming Cheng
    7 Cheng
  5. Steven M Larson
    959 Larson
  6. Sarah Marie Cheal
    49 Cheal
  7. Hong-Fen Guo
    74 Guo
  8. Qi Zhao
    5 Zhao
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