Precision medicine at Memorial Sloan Kettering Cancer Center: Clinical next-generation sequencing enabling next-generation targeted therapy trials Journal Article
| Authors: | Hyman, D. M.; Solit, D. B.; Arcila, M. E.; Cheng, D. T.; Sabbatini, P.; Baselga, J.; Berger, M. F.; Ladanyi, M. |
| Article Title: | Precision medicine at Memorial Sloan Kettering Cancer Center: Clinical next-generation sequencing enabling next-generation targeted therapy trials |
| Abstract: | Implementing a center-wide precision medicine strategy at a major cancer center is a true multidisciplinary effort and requires comprehensive alignment of a broad screening strategy with a clinical research enterprise that can use these data to accelerate development of new treatments. Here, we describe the genomic screening approach at Memorial Sloan Kettering Cancer Center, a hybridization capture-based next-generation sequencing clinical assay for solid tumor molecular oncology designated MSK-IMPACT, and how it enables and supports a large clinical trial portfolio enriched for multi-histology, biomarker-selected, 'basket' studies of targeted therapies. © 2015 Elsevier Ltd. All rights reserved. |
| Keywords: | somatic mutation; review; solid tumor; gene expression profiling; genetic variability; cancer center; clinical research; molecularly targeted therapy; next generation sequencing; exome; human |
| Journal Title: | Drug Discovery Today |
| Volume: | 20 |
| Issue: | 12 |
| ISSN: | 1359-6446 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2015-12-01 |
| Start Page: | 1422 |
| End Page: | 1428 |
| Language: | English |
| DOI: | 10.1016/j.drudis.2015.08.005 |
| PROVIDER: | scopus |
| PUBMED: | 26320725 |
| PMCID: | PMC4940024 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 7 January 2016 -- 1422 -- Source: Scopus |
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