Comorbidities, smoking status, and life expectancy among individuals eligible for lung cancer screening Journal Article


Authors: Howard, D. H.; Richards, T. B.; Bach, P. B.; Kegler, M. C.; Berg, C. J.
Article Title: Comorbidities, smoking status, and life expectancy among individuals eligible for lung cancer screening
Abstract: BACKGROUND Lung cancer screening recommendations are based on results from the National Lung Screening Trial (NLST). The authors determined how the screening-eligible US population differs from NLST participants in terms of characteristics that affect their ability to benefit from screening. METHODS The authors identified respondents to the 2012 Health and Retirement Study (HRS), a national survey of individuals aged ?50 years who are eligible for screening based on US Preventive Services Task Force and Centers for Medicare and Medicaid Services criteria. Comorbidities, life expectancy, smoking history, and other characteristics were compared between the screening-eligible population and NLST participants. RESULTS The authors estimated that in 2013, 8.4 million individuals (95% confidence interval, 7.9-8.9 million individuals) would have met the eligibility criteria for lung cancer screening established by the US Preventive Services Task Force. Compared with NLST participants, HRS screening-eligible respondents were older, more likely to be current smokers, and more likely to have been diagnosed with comorbidities. The 5-year survival rate was 87% in the HRS screening-eligible individuals versus 93% in the NLST participants (P<.001, based on a 2-sided test). Life expectancy was 18.7 years in the HRS screening-eligible individuals versus 21.2 years in the NLST participants. CONCLUSIONS The US population eligible for lung cancer screening is probably less likely to benefit from early detection than NLST participants because they face a high risk of death from competing causes. The results of the current study highlight the need for smoking cessation interventions targeting those patients eligible for screening and tools to help clinicians determine the potential benefits of screening in individual patients. Cancer 2015;121:4341-7. © 2015 American Cancer Society.
Keywords: adult; aged; united states; lung neoplasms; cancer screening; lung cancer; smoking; age; risk assessment; self report; early diagnosis; comorbidity; age distribution; cancer classification; life expectancy; early detection of cancer; population characteristics; human; male; female; priority journal; article
Journal Title: Cancer
Volume: 121
Issue: 24
ISSN: 0008-543X
Publisher: Wiley Blackwell  
Date Published: 2015-12-15
Start Page: 4341
End Page: 4347
Language: English
DOI: 10.1002/cncr.29677
PROVIDER: scopus
PMCID: PMC4670572
PUBMED: 26372542
DOI/URL:
Notes: Article -- 1 -- Export Date: 7 January 2016 -- 4341 -- Source: Scopus
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  1. Peter Bach
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