Optimal surgical management for high-risk populations Conference Paper
| Authors: | King, T. A.; Pilewskie, M.; Morrow, M. |
| Title: | Optimal surgical management for high-risk populations |
| Conference Title: | 14th St.Gallen International Breast Cancer Conference |
| Abstract: | The recognition that breast cancer is a group of genetically distinct diseases with differing responses to treatment and varying patterns of both local and systemic failure has led to many questions regarding optimal therapy for those considered to be high risk. Young patients, patients with triple-negative breast cancer (TNBC), and those who harbor a deleterious mutation in BRCA1 or BRCA2 are frequently considered to be at highest risk of local failure, leading to speculation that more-aggressive surgical treatment is warranted in these patients. For both age and the triple-negative subtype, it appears that the intrinsic biology which imparts inferior outcomes is not overcome with mastectomy; therefore, a recommendation for more extensive surgical therapy among these higher-risk groups is not warranted. For those at inherited risk, a more-aggressive surgical approach may be preferable, however; patient age, ER status, stage of the index lesion, and individual patient preferences should all be considered in the surgical decision-making process. © 2015. |
| Keywords: | cancer survival; treatment response; cancer surgery; survival rate; gene mutation; cancer recurrence; cancer risk; treatment planning; outcome assessment; medical decision making; cancer prevention; breast cancer; mastectomy; risk factor; age; risk assessment; tumor suppressor gene; high risk population; breast surgery; young age; triple negative breast cancer; brca mutation; human; priority journal; article; triple-negative subtype |
| Journal Title | Breast |
| Volume: | 24 |
| Issue: | Suppl. 2 |
| Conference Dates: | 2015 Mar 18-21 |
| Conference Location: | Vienna, Austria |
| ISBN: | 0960-9776 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2015-11-01 |
| Start Page: | S91 |
| End Page: | S95 |
| Language: | English |
| DOI: | 10.1016/j.breast.2015.07.022 |
| PROVIDER: | scopus |
| PUBMED: | 26432360 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 7 January 2016 -- S91 -- Source: Scopus |
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