Mutation of cell cycle regulators and their impact on superficial bladder cancer Journal Article

  


Authors: Rabbani, F.; Cordon-Cardo, C.
Article Title: Mutation of cell cycle regulators and their impact on superficial bladder cancer
Abstract: Early cytogenetic studies in bladder cancer identify regions of chromosomal gain or loss that can be candidate loci for oncogenes and tumor suppressor genes. Oncogenes with potential prognostic significance identified in bladder cancer the RAS family, epidermal growth factor receptor, ERBB-2, MDM2, and cyclin D1. The TP53 gene has been the most thoroughly characterized tumor suppressor gene in bladder cancer, with correlation of TP53 alterations with type of carcinogenic exposure, tumor stage and grade, as well as prognosis. Studies evaluating alterations of the retinoblastoma pathway have identified the retinoblastoma gene, RB, p161NK4A/CDKN2, and E2F-1 as tumor suppressor genes with potential prognostic significance in patients with bladder cancer. Better understanding of the genetic mechanisms underlying bladder tumor development and progression will allow better prevention, diagnosis, and treatment strategies.
Keywords: gene mutation; mutation; review; in situ hybridization, fluorescence; cell cycle; gene locus; cytogenetics; retinoblastoma; bladder cancer; urinary bladder neoplasms; carcinogenesis; oncogene; gene expression regulation, neoplastic; chromosome loss; genes, tumor suppressor; proto-oncogenes; genes, retinoblastoma; humans; prognosis; human; priority journal
Journal Title: Urologic Clinics of North America
Volume: 27
Issue: 1
ISSN: 0094-0143
Publisher: W.B. Saunders Co-Elsevier Inc.  
Date Published: 2000-02-01
Start Page: 83
End Page: 102
Language: English
PUBMED: 10696248
PROVIDER: scopus
DOI: 10.1016/S0094-0143(05)70237-8
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-0033951771&partnerID=40&md5=974d0ba62981eb82a7ac99d4df481c66
Notes: Export Date: 18 November 2015 -- Source: Scopus
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MSK Authors
  1. Farhang Rabbani
    84 Rabbani
  2. Carlos Cordon-Cardo
    612 Cordon-Cardo
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