Remarkable roles of proteolysis on and beyond the cell surface Journal Article
| Author: | Blobel, C. P. |
| Article Title: | Remarkable roles of proteolysis on and beyond the cell surface |
| Abstract: | Proteolysis on the cell surface and in the extracellular matrix is essential for normal cellular functions during development and in the adult, but it may also have undesirable consequences, such as promoting cancer, arthritis, and Alzheimer's disease. Recent advances highlight the roles of zinc-dependent metalloproteinases (metzincins) in proper skeletal development, in activating EGF-receptor ligands, in Notch-dependent signaling, and in initiating and promoting tumorigenesis. |
| Keywords: | review; animals; cell function; protein degradation; epidermal growth factor receptor; membrane proteins; extracellular matrix; cytokine; cytokines; tumor necrosis factor alpha; arthritis; autocrine effect; cell migration; gene control; cytokine production; tumor promotion; bone development; zinc; alzheimer disease; metalloproteinase; matrix metalloproteinases; receptors, cell surface; matrilysin; cell surface; growth substances; humans; priority journal |
| Journal Title: | Current Opinion in Cell Biology |
| Volume: | 12 |
| Issue: | 5 |
| ISSN: | 0955-0674 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2000-10-01 |
| Start Page: | 606 |
| End Page: | 612 |
| Language: | English |
| DOI: | 10.1016/s0955-0674(00)00139-3 |
| PUBMED: | 10978897 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 18 November 2015 -- Source: Scopus |
