Applying topological principles to genomic analysis Journal Article
| Authors: | Emmett, K.; Chan, J. M.; Rosenbloom, D. S.; Rabadan, R. |
| Article Title: | Applying topological principles to genomic analysis |
| Abstract: | Horizontal gene transfers, particularly among microorganisms, complicate efforts to analyze and depict phylogenetic relationships. Topological data analysis provides a novel approach to characterizing both vertical and horizontal modes of evolution that are embedded in genomic datasets. Aligned genomic sequences can be viewed as points in a high-dimensional sequence space; applying persistent homology analysis to these spaces then enables us to read off phylogenetic information from resulting barcode diagrams. This analytic approach can be used to gain insights into the recent evolution of viral and bacterial pathogens. © 2015, American Society for Microbiology. All rights reserved. |
| Journal Title: | Microbe |
| Volume: | 10 |
| Issue: | 11 |
| ISSN: | 1558-7452 |
| Publisher: | American Society for Microbiology |
| Date Published: | 2015-11-01 |
| Start Page: | 467 |
| End Page: | 473 |
| Language: | English |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 2 December 2015 -- Source: Scopus |
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