Myoepithelial carcinoma of the extremity: Response to isolated limb infusion Journal Article
| Authors: | Fitzgerald, M. J.; Busam, K.; Athanasian, E.; Brady, M. S. |
| Article Title: | Myoepithelial carcinoma of the extremity: Response to isolated limb infusion |
| Abstract: | We report our experience with two patients with myoepithelial carcinoma (MEC) of the extremity. An 83-year-old male and a 35-year-old female were treated with standard isolated limb infusion (ILI), using melphalan and dactinomycin. The first patient had a complete response (CR) that was sustained for two and a half years, until he developed a regional lymph node metastasis. The second patient had a 4.7 cm tumor located on her left hand with metastasis to the ipsilateral axillary lymph nodes. Initial treatment consisted of ILI and left axillary lymphadenectomy. The primary tumor regressed and showed signs of central necrosis, measuring 2.8 cm after 1 month. Though she was continuing to respond, a decision was made by her orthopedic surgeon to administer neoadjuvant radiation followed by surgical resection. © 2015 Wiley Periodicals, Inc. |
| Keywords: | immunohistochemistry; adult; cancer chemotherapy; treatment response; aged; case report; drug efficacy; chemotherapy; cancer staging; nuclear magnetic resonance imaging; lymph node metastasis; lymph node dissection; ki 67 antigen; tumor localization; tumor volume; melphalan; oncology; axillary lymph node; fluorescence in situ hybridization; gene rearrangement; cutaneous; computer assisted emission tomography; carcinoma; dactinomycin; isolated limb infusion; regional perfusion; cytoplasm; protein s 100; mitosis rate; calponin; cytokeratin 7; synovial sarcoma; soft tissue tumor; cytokeratin ae1; cytokeratin ae3; epithelial membrane antigen; vimentin; myoepithelioma; myoepithelial carcinoma; preoperative radiotherapy; hand tumor; fine needle aspiration biopsy; ganglion cyst; knee pain; knee arthroplasty; very elderly; human; male; female; priority journal; article; angiographic catheter; knee arthritis |
| Journal Title: | Journal of Surgical Oncology |
| Volume: | 112 |
| Issue: | 5 |
| ISSN: | 0022-4790 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2015-10-01 |
| Start Page: | 510 |
| End Page: | 513 |
| Language: | English |
| DOI: | 10.1002/jso.24014 |
| PROVIDER: | scopus |
| PUBMED: | 26288004 |
| DOI/URL: | |
| Notes: | Export Date: 2 December 2015 -- Source: Scopus |
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