Case-control study of second-line therapies for type 2 diabetes in combination with metformin and the comparative risks of myocardial infarction and stroke Journal Article
| Authors: | Floyd, J. S.; Wiggins, K. L.; Sitlani, C. M.; Flory, J. H.; Dublin, S.; Smith, N. L.; Heckbert, S. R.; Psaty, B. M. |
| Article Title: | Case-control study of second-line therapies for type 2 diabetes in combination with metformin and the comparative risks of myocardial infarction and stroke |
| Abstract: | We conducted a population-based case-control study to assess the myocardial infarction (MI) and stroke risks associated with sulphonylureas and insulin when used in combination with metformin. Cases had type 2 diabetes and used metformin + insulin or metformin + sulphonylureas at the time of a first MI or first stroke between 1995 and 2010; controls used the same treatment combinations and were randomly sampled from the same population. MI and stroke diagnoses and potential confounders were validated by medical record reviews. Compared with metformin + sulphonylurea, metformin + insulin was associated with similar risks of MI or stroke [odds ratio 0.98 (95% confidence interval 0.63-1.52)]. Meta-analysis with another observational study improved the precision of the risk estimate [relative risk 0.92 (95% confidence interval 0.69-1.24)]. Current evidence suggests that there may not be large differences in cardiovascular risk associated with the use of insulin or sulphonylureas when used in combination with metformin. © 2015 John Wiley & Sons Ltd. |
| Keywords: | adult; controlled study; major clinical study; drug safety; letter; medical record review; cardiovascular risk; heart infarction; stroke; insulin; observational study; metformin; sulfonylurea derivative; non insulin dependent diabetes mellitus; myocardial infarction; cerebrovascular accident; population based case control study; case-control study; human; male; female; cardiovascular outcomes; comparative safety; sulphonylureas |
| Journal Title: | Diabetes, Obesity and Metabolism |
| Volume: | 17 |
| Issue: | 12 |
| ISSN: | 1462-8902 |
| Publisher: | John Wiley & Sons |
| Date Published: | 2015-12-01 |
| Start Page: | 1194 |
| End Page: | 1197 |
| Language: | English |
| DOI: | 10.1111/dom.12537 |
| PROVIDER: | scopus |
| PMCID: | PMC4626290 |
| PUBMED: | 26179389 |
| DOI/URL: | |
| Notes: | Export Date: 2 December 2015 -- Source: Scopus |
