Notch inhibition in desmoids: "Sure it works in practice, but does it work in theory?" Journal Article
| Author: | Gounder, M. M. |
| Article Title: | Notch inhibition in desmoids: "Sure it works in practice, but does it work in theory?" |
| Abstract: | The biology of inhibiting Notch and potentially other targets of γ-secretase in desmoid tumors is examined. © 2015 American Cancer Society. |
| Keywords: | immunohistochemistry; signal transduction; protein expression; treatment response; cancer surgery; review; sorafenib; doxorubicin; drug efficacy; alpha interferon; cancer incidence; imatinib; apoptosis; transforming growth factor beta; sonic hedgehog protein; notch receptor; tumor biopsy; transcription factor hes 1; cell differentiation; mutational analysis; cancer mortality; scleroprotein; wound healing; gene expression regulation; cancer inhibition; genome analysis; oncogene; mononuclear cell; messenger rna; sulindac; cancer cell; nerve cell adhesion molecule; collagen; fibroblast; tamoxifen; mesenchymal stem cell; inhibition kinetics; upregulation; hyaluronic acid; tissue microarray; myofibroblast; chromosome 8; hermes antigen; homeostasis; tumor vascularization; beta catenin; wnt protein; antiangiogenic activity; chromosome 6; pleiotropy; metalloproteinase; adenomatous polyp; notch1 receptor; desmoid tumor; epidermal growth factor receptor 4; jagged1; chromosome 20; ephrin b2; chromosome 5; apc gene; wnt signaling pathway; ctnnb1 gene; g1 phase cell cycle checkpoint; human; priority journal; ipafricept; pf 3084014; wisp2 gene |
| Journal Title: | Cancer |
| Volume: | 121 |
| Issue: | 22 |
| ISSN: | 0008-543X |
| Publisher: | Wiley Blackwell |
| Date Published: | 2015-11-15 |
| Start Page: | 3933 |
| End Page: | 3937 |
| Language: | English |
| DOI: | 10.1002/cncr.29562 |
| PROVIDER: | scopus |
| PUBMED: | 26348868 |
| DOI/URL: | |
| Notes: | Export Date: 2 December 2015 -- Source: Scopus |
