Inhibition of metabolic activity in papillary thyroid carcinoma by a somatostatin analogue Journal Article

  


Authors: Robbins, R. J.; Hill, R. H.; Wang, W.; Macapinlac, H.; Larson, S. M.
Article Title: Inhibition of metabolic activity in papillary thyroid carcinoma by a somatostatin analogue
Abstract: Two patients with widely metastatic papillary thyroid cancer demonstrated progressive growth of diffuse pulmonary lesions. One patient had no apparent response to high doses of 131I and the other hand no 131I uptake. 111In-pentetreotide scans revealed that many of the metastatic lesions expressed somatostatin receptors. The baseline metabolic activity and three-dimensional volume of the lesions were determined by 18F-fluoro- deoxyglucose positron emission tomography (FDG-PET). After 3 or 4 months of octreotide (Sandostatin LAR Depot®; Novartis Pharmaceutical, East Hanover, NJ) therapy, repeat FDG-PET scans revealed reductions in tumor volume and decreases in the standard uptake values of FDG. We conclude that octreotide therapy can change the biological activity of metastatic thyroid cancer lesions that exhibit somatostatin receptors.
Keywords: adult; treatment outcome; middle aged; case report; radiopharmaceuticals; tumor volume; carcinoma, papillary; lung metastasis; iodine 131; fluorodeoxyglucose f18; thyroid neoplasms; octreotide; antineoplastic agents, hormonal; thyroid papillary carcinoma; somatostatin; tomography, emission-computed; pentetreotide; somatostatin receptor; tomography, emission-computed, single-photon; delayed-action preparations; thyroid scintiscanning; humans; human; male; female; priority journal; article; receptors, somatostatin
Journal Title: Thyroid
Volume: 10
Issue: 2
ISSN: 1050-7256
Publisher: Mary Ann Liebert, Inc  
Date Published: 2000-02-01
Start Page: 177
End Page: 183
Language: English
PUBMED: 10718556
PROVIDER: scopus
DOI: 10.1089/thy.2000.10.177
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-0033997649&partnerID=40&md5=b076471188596c3b666ae87a6a7452d2
Notes: Export Date: 18 November 2015 -- Source: Scopus
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MSK Authors
  1. Richard J Robbins
    54 Robbins
  2. Homer Macapinlac
    106 Macapinlac
  3. Steven M Larson
    959 Larson
  4. Weiping Wang
    7 Wang
  5. Robert H Hill
    1 Hill
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