In pursuit of an anticancer vaccine: A monomolecular construct containing multiple carbohydrate antigens Journal Article
| Authors: | Williams, L. J.; Harris, C. R.; Glunz, P. W.; Danishefsky, S. J. |
| Article Title: | In pursuit of an anticancer vaccine: A monomolecular construct containing multiple carbohydrate antigens |
| Abstract: | The synthesis of a new type of anti-cancer vaccine candidate is presented. This compound contains the TF, Le(y), and Tn tumor antigens clustered in a monomolecular array. In addition to being a realistic mimic of 'micro-heterogeneous' mucins, this class of vaccine may trigger a multifaceted immune response convergent on a particular cancer type. (C) 2000 Elsevier Science Ltd. |
| Keywords: | antineoplastic agent; antineoplastic activity; immune response; cancer vaccine; vaccination; peptides; synthesis; vaccine; carbohydrates; carbohydrate antigen; mucin; molecular mimicry; monosaccharide; disaccharide; article; anti-cancer vaccines; tumor-associated carbohydrate antigens |
| Journal Title: | Tetrahedron Letters |
| Volume: | 41 |
| Issue: | 49 |
| ISSN: | 0040-4039 |
| Publisher: | Pergamon-Elsevier Science Ltd |
| Date Published: | 2000-12-02 |
| Start Page: | 9505 |
| End Page: | 9508 |
| Language: | English |
| PROVIDER: | scopus |
| DOI: | 10.1016/S0040-4039(00)01656-7 |
| DOI/URL: | |
| Notes: | Export Date: 18 November 2015 -- Source: Scopus |
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539Danishefsky
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