Extraskeletal osteosarcoma: Analysis of outcome of a rare neoplasm Journal Article

Authors: Mccarter, M. D.; Lewis, J. J.; Antonescu, C. R.; Brennan, M. F.
Article Title: Extraskeletal osteosarcoma: Analysis of outcome of a rare neoplasm
Abstract: Purpose. Extraskeletal osteosarcoma represents an unusual soft-tissue sarcoma that historically is reported to carry an exceptionally poor prognosis. The objectives of this study were to use a prospectively gathered sarcoma database to test the prevailing clinical bias and more accurately describe the natural history, characterize the prognostic features, estimate survival and evaluate treatment strategies for this unusual sarcoma. Patients and methods. From a large database of nearly 4000 sarcomas at a single institution, 15 patients with pathologically confirmed extraskeletal osteosarcoma were analysed. Results and discussion. Extraskeletal osteosarcoma usually occurs as a large, deep, high-grade lesion in the lower extremity of older patients. Overall and disease-specific survival at 5 years was 50%, with a median follow-up of 35 months (range 3-200 months). Use of adjuvant chemotherapy or radiation therapy did not appear to influence survival, but an effect may have been missed by the relatively low numbers in each group. When matched to a comparable group of patients with stage III extremity sarcomas, there was no significant difference in overall or disease-specific survival between groups. Treatment for extraskeletal osteosarcoma should follow established guidelines for treatment of soft-tissue sarcomas, with the decision regarding adjuvant therapy to be based on individual risk factors.
Keywords: osteosarcoma; adult; cancer survival; aged; cancer staging; cancer grading; risk factor; outcome; outcomes research; prospective; prognosis; human; male; female; priority journal; article; extraskeletal sarcoma
Journal Title: Sarcoma
Volume: 4
Issue: 3
ISSN: 1357-714X
Publisher: Hindawi Publishing Corporation  
Date Published: 2000-09-01
Start Page: 119
End Page: 123
Language: English
PROVIDER: scopus
PMCID: PMC2395433
PUBMED: 18521290
DOI: 10.1080/13577140020008084
Notes: Export Date: 18 November 2015 -- Source: Scopus
Altmetric Score
MSK Authors
  1. Murray F Brennan
    800 Brennan
  2. Jonathan J Lewis
    107 Lewis
  3. Cristina R Antonescu
    627 Antonescu