Tumour control probability: A formulation applicable to any temporal protocol of dose delivery Journal Article
| Authors: | Zaider, M.; Minerbo, G. N. |
| Article Title: | Tumour control probability: A formulation applicable to any temporal protocol of dose delivery |
| Abstract: | An analytic expression for the tumour control probability (TCP), valid for any temporal distribution of dose, is discussed. The TCP model, derived using the theory of birth-and-death stochastic processes, generalizes several results previously obtained. Equivalently, b = 0.693/T(pot) and d/b is the cell loss factor of the tumour. In this expression t refers to any time during or after the treatment; typically, one would take for t the end of the treatment period or the expected remaining life span of the patient. This model, which provides a comprehensive framework for predicting TCP, can be used predictively, or - when clinical data are available for one particular treatment modality (e.g. fractionated radiotherapy) - to obtain TCP- equivalent regimens for other modalities (e.g. low dose-rate treatments). |
| Keywords: | survival rate; cancer radiotherapy; radiation dose; sensitivity and specificity; neoplasms; radiotherapy dosage; probability; brachytherapy; radiotherapy planning, computer-assisted; cancer control; dose fractionation; radiation dose distribution; stochastic model; theory; mathematical analysis; humans; priority journal; article |
| Journal Title: | Physics in Medicine and Biology |
| Volume: | 45 |
| Issue: | 2 |
| ISSN: | 0031-9155 |
| Publisher: | IOP Publishing Ltd |
| Date Published: | 2000-02-01 |
| Start Page: | 279 |
| End Page: | 293 |
| Language: | English |
| DOI: | 10.1088/0031-9155/45/2/303 |
| PUBMED: | 10701504 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 18 November 2015 -- Source: Scopus |
