New approaches in the treatment of metastatic melanoma: Thalidomide and temozolomide Journal Article
| Author: | Hwu, W. J. |
| Article Title: | New approaches in the treatment of metastatic melanoma: Thalidomide and temozolomide |
| Abstract: | Although melanoma is a relatively chemorexistant malignancy, systemic chemotherapy remains the primary treatment for metastatic melanoma. The observation of vasculogenic mimicry in aggressive melanoma has prompted investigation into using an antiangiogenic agent to enhance the antitumor activity of chemotherapy in metastatic melanoma. Thalidomide (Thalomid) exhibits antiangiogenic activity and other biological modulatory effects that may provide additive or synergistic antitumor effects when given concurrently with chemotherapy. A phase I/II study of thalidomide and temozolomide in the treatment of metastatic melanoma is in progress. Preliminary results of this combination therapy have shown significant antitumor activity, including some striking responses in brain metastases. |
| Keywords: | adult; middle aged; thalidomide; review; case report; angiogenesis inhibitor; temozolomide; antineoplastic agent; dacarbazine; melanoma; metastasis; phase 2 clinical trial; antineoplastic combined chemotherapy protocols; alkylating agent; antineoplastic agents, alkylating; neoplasm metastasis; drug derivative; phase 1 clinical trial; angiogenesis inhibitors; clinical trials, phase ii; clinical trials, phase i; humans; human; male; female |
| Journal Title: | Oncology (Norwalk) |
| Volume: | 14 |
| Issue: | 12 Suppl. 13 |
| ISSN: | 0890-9091 |
| Publisher: | C M P Medica LLC * The Oncology Group |
| Date Published: | 2000-12-01 |
| Start Page: | 25 |
| End Page: | 28 |
| Language: | English |
| PUBMED: | 11204670 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 18 November 2015 -- Source: Scopus |
