| Abstract: |
Whether fibromatoses are neoplastic or reactive lesions has long been controversial and the relationship, if any, between fine superficial and deep forms (desmoid tumors) are poorly understood. Clinical, pathologic, and cytogenetic data of 78 cases of fibromatosis were analyzed and correlated with each other. The results demonstrate that clonal chromosome aberrations are a common feature of this entity, being present in 46% of desmoid tumors, although less frequent in the superficial types (10%). In the deep-seated extra-abdominal fibromatoses, trisomies 8 and 20 and loss of 5q material were the only recurrent features. No correlation between +8 and local recurrence was found. Our findings provide additional evidence for the neoplastic nature of fibromatoses. |
| Keywords: |
adult; child; aged; aged, 80 and over; middle aged; gene mutation; incidence; cytogenetics; chromosomes, human, pair 8; chromosome aberration; recurrent disease; fibroma; chromosome aberrations; karyotype; karyotyping; clone cells; soft tissue neoplasms; soft tissue tumor; peyronie disease; desmoid tumor; single-blind method; fibromatosis; fibromatosis, aggressive; trisomy; chromosomes, human, pair 20; chromosome 5q; trisomy 8; multicenter studies; soft tissue tumors; humans; human; male; female; priority journal; article; desmoid; fibromatoses; abdominal fibromatosis; dupuytren contracture
|
