| Abstract: |
Recent studies have analyzed the expression of chemokines in tissues involved by Hodgkin's disease (HD). The data indicate a significant role for chemokine expression in the pathobiology and pathophysiology of HD. In general, HD tissues showed higher levels of chemokine expression than reactive lymphoid hyperplasia (RLH) tissues. There were major differences in chemokine expression among the different HD subtypes. Similar to previous studies in athymic mice that identified a pattern of chemokine response induced by Epstein-Barr virus (EBV)-infected cells, the expression of IP-10, Mig, RANTES, and MIP1-α was higher in EBV positive compared to EBV negative HD tissues. In addition, there was a direct correlation of eotaxin expression with tissue eosinophilia. By immunohistochemistry, IP-10 and Mig proteins localized in the malignant Reed-Sternberg (RS) cells and their variants, and to some surrounding inflammatory cells. Eotaxin localized to fibroblasts and smooth muscle of blood vessels. In this review, we discuss the patterns of expression of IP-10, Mig, RANTES, MIP1-α, and eotaxin in HD and its subtypes, and the relationship to EBV positivity, LMP1 expression, tissue eosinophilia and T cell infiltration. In addition, we discuss the potential role of chemokines and cytokines in the pathobiology of HD. |
| Keywords: |
immunohistochemistry; clinical article; human tissue; protein expression; intercellular signaling peptides and proteins; pathophysiology; t lymphocyte; animals; mice; gene expression profiling; eotaxin; inflammatory cell; hodgkin disease; gene expression regulation, neoplastic; cytokines; chemokine; tissue distribution; mice, nude; messenger rna; reverse transcriptase polymerase chain reaction; hyperplasia; fibroblast; tumor virus infections; t-lymphocyte subsets; lymphocytic infiltration; viral matrix proteins; epstein barr virus; chemokine ccl2; chemokines; chemotaxis, leukocyte; cell transformation, viral; herpesvirus 4, human; reed sternberg cell; reed-sternberg cells; epstein-barr virus infections; interleukin-13; vascular smooth muscle; eosinophilia; lymphatic diseases; rantes; alpha chemokine; macrophage inflammatory protein 1alpha; hodgkin's disease; chemokines, cxc; chemokines, cc; macrophage inflammatory protein-1; ip-10; humans; human; female; priority journal; article; mip1-α
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