| Abstract: |
The ret/PTC rearrangements (PTC-1, PTC-2, and PTC-3) are characteristic of papillary thyroid cancer (PTC). In adults, PTC-1 is common and may be associated with an aggressive clinical course. The incidence and significance of ret/PTC mutations are less well understoodin children. We examined spontaneous PTC from 33 patients (23 females and 10 males) with a median age of 18 yr (range, 6-21 yr) and a median follow-up of 3.5 yr (range, 0-13.4 yr). The ret/PTC mutations were identified in 15 tumors (45%), including 8 PTC-1 (8 of 15, 53%), 2 PTC-2 (2 of 15, 13%), 2 PTC-3 (2 of 15, 13%), and 3 (3 of 15, 20%) combined PTC mutations (PTC-1 and PTC-2). This distribution is significantly different (P = 0.001, by X2 analysis) from that reported for children with radiation-induced PTC. There was no correlation between the presence or type of ret/PTC mutation and patient age, tumor size, focality, extent of disease at diagnosis, or recurrence. We conclude that ret/PTC mutations are 1) common in sporadic childhood PTC, 2) predominantly PTC-1, 3) frequently multiple, and 4) of different distribution than that reported for children with radiation-induced PTC. |
| Keywords: |
adolescent; adult; child; clinical article; controlled study; human tissue; unclassified drug; gene mutation; mutation; disease course; cancer recurrence; follow up; genetic analysis; cohort studies; tumor volume; carcinoma, papillary; gene product; radiation injury; age; carcinogenesis; disease severity; registries; gene rearrangement; reverse transcriptase polymerase chain reaction; oncogene proteins, fusion; thyroid carcinoma; thyroid neoplasms; protein-tyrosine kinases; papillary carcinoma; rna, neoplasm; child care; dna, complementary; oncogene ret; ukraine; protein patched; correlation function; accidents, radiation; humans; human; male; female; priority journal; article
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