Perioperative alterations in plasma endothelin-1 and echocardiographic correlates of right heart function Journal Article
| Authors: | Amar, D.; Fleisher, M.; Leung, D. H. Y.; Zhang, H.; Ginsburg, I.; Roistacher, N. |
| Article Title: | Perioperative alterations in plasma endothelin-1 and echocardiographic correlates of right heart function |
| Abstract: | Objective: To determine whether greater changes in plasma endothelin-1 (ET-1) concentrations and right ventricular systolic pressure occur after major thoracic surgery than after major abdominal operations. Design: Prospective study. Setting: University hospital. Participants: Patients undergoing elective thoracotomies (n = 12) or laparotomies (n = 10). Interventions: ET-1 was measured from blood obtained before anesthesia and again on postoperative days 1, 2, 3, and 5 (or 6). Transthoracic echocardiography was performed before surgery and on postoperative day 2 to evaluate right-sided heart function. Measurements and Main Results: After abdominal and thoracic surgery, systemic and estimated pulmonary vascular pressures were normal in both groups and unaffected by surgery. Plasma ET-1 concentrations decreased from baseline values during the first postoperative week with no differences between the groups. Conclusions: In patients without organic heart disease, plasma ET-1 levels do not increase in response to major abdominal or thoracic surgery. Whether or not plasma ET-1 concentrations are elevated in patients developing clinically significant postoperative pulmonary hypertension requires further study. Copyright (C) 2000 by W.B. Saunders Company. |
| Keywords: | clinical article; aged; middle aged; postoperative period; laparotomy; thoracotomy; midazolam; surgery; blood pressure; perioperative period; abdominal surgery; echocardiography; postoperative pain; morphine sulfate; heart; monitoring, intraoperative; transthoracic echocardiography; fentanyl; heart function; anesthesia; surgical patient; thiopental; isoflurane; pulmonary hypertension; endothelin 1; radioimmunoassay; glycopyrronium bromide; nitrous oxide; endothelin-1; pulmonary circulation; heart function tests; humans; human; male; female; priority journal; article; heart right ventricle pressure |
| Journal Title: | Journal of Cardiothoracic and Vascular Anesthesia |
| Volume: | 14 |
| Issue: | 2 |
| ISSN: | 1053-0770 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2000-04-01 |
| Start Page: | 140 |
| End Page: | 143 |
| Language: | English |
| PUBMED: | 10794331 |
| PROVIDER: | scopus |
| DOI: | 10.1016/S1053-0770(00)90007-7 |
| DOI/URL: | |
| Notes: | Export Date: 18 November 2015 -- Source: Scopus |
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