Alpha-fetoprotein production by pancreatic tumors exhibiting acinar cell differentiation: Study of five cases, one arising in a mediastinal teratoma Journal Article
| Authors: | Cingolani, N.; Shaco-Levy, R.; Farruggio, A.; Klimstra, D. S.; Rosai, J. |
| Article Title: | Alpha-fetoprotein production by pancreatic tumors exhibiting acinar cell differentiation: Study of five cases, one arising in a mediastinal teratoma |
| Abstract: | Five cases of pancreatic neoplasms accompanied by production of alpha-fetoprotein (AFP) and serum elevation of this marker are presented, and the better-documented cases of this phenomenon from the literature are reviewed. Four of the cases originated in the orthotopic pancreas, whereas the fifth arose in the pancreatic component of a mediastinal teratoma. The patients were children or young adults. AFP production in pancreatic tumors is closely linked to acinar differentiation, most cases representing either pancreatoblastoma or acinar cell carcinoma. The distinction between these 2 tumors may be difficult because of the many morphologic and immunohistochemical features they share. Copyright (C) 2000 by W.B. Saunders Company. |
| Keywords: | immunohistochemistry; adolescent; adult; child; clinical article; pancreatic neoplasms; pancreas; carcinoembryonic antigen; cell differentiation; tumor marker; morphology; pancreas tumor; protein secretion; teratoma; acinar cell carcinoma; mediastinum tumor; mediastinal neoplasms; chymotrypsin; acinar cell; alpha-fetoprotein; alpha fetoprotein; trypsin; pancreatoblastoma; alpha-fetoproteins; chromogranins; afp; humans; human; male; female; article |
| Journal Title: | Human Pathology |
| Volume: | 31 |
| Issue: | 8 |
| ISSN: | 0046-8177 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2000-08-01 |
| Start Page: | 938 |
| End Page: | 944 |
| Language: | English |
| DOI: | 10.1053/hupa.2000.9075 |
| PUBMED: | 10987254 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 18 November 2015 -- Source: Scopus |
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