Recognition of intrabiliary hepatic metastases from colorectal adenocarcinoma Journal Article
| Authors: | Povoski, S. P.; Klimstra, D. S.; Brown, K. T.; Schwartz, L. H.; Kurtz, R. C.; Jarnagin, W. R.; Fong, Y.; Blumgart, L. H. |
| Article Title: | Recognition of intrabiliary hepatic metastases from colorectal adenocarcinoma |
| Abstract: | Intrinsic involvement of bile ducts, by metastatic colorectal adenocarcinoma growing from within or invading the lumen of bile ducts, is not a well recognized pattern of tumor growth. Clinical, radiographic, operative, and histopathologic aspects of 15 patients with intrabiliary colorectal metastases were described. Fourteen patients were explored for possible hepatic resection. Two had jaundice, two radiographic evidence of an intrabiliary filling defect, 10 intraoperative evidence of intrabiliary tumor, and six microscopic evidence of intrabiliary tumor. Eleven patients underwent hepatic resection. Five of the resected patients developed hepatic recurrence. Four patients were explored for possible repeat resection. One had jaundice, one radiographic evidence of an intrabiliary filling defect, all had intraoperative evidence of intrabiliary tumor, and three microscopic evidence of intrabiliary tumor. Three patients underwent repeat hepatic resection. All patients with preoperative jaundice and radiographic evidence of an intrabiliary filling defect were unresectable. Overall, actuarial five-year survival is 33% for those patients resected versus 0% for those not resected. Intraoperative recognition of intrabiliary tumor at exploration for hepatic resection was more common than clinical, radiographic, or histopathologic recognition. More diligent examination of resected liver tissue by the surgeon and pathologist may increase identification of bile duct involvement and aid in achieving adequate tumor clearance. |
| Keywords: | adult; cancer survival; clinical article; controlled study; aged; aged, 80 and over; middle aged; histopathology; cancer recurrence; liver neoplasms; colorectal cancer; adenocarcinoma; neoplasm recurrence, local; colorectal carcinoma; colorectal neoplasms; cancer invasion; liver metastasis; reoperation; jaundice; liver resection; hepatectomy; bile duct neoplasms; bile ducts, intrahepatic; tumor growth; metastases; radiodiagnosis; clinical examination; bile duct; bile duct tumor; hepatic; biliary; humans; human; male; female; priority journal; article |
| Journal Title: | HPB Surgery |
| Volume: | 11 |
| Issue: | 6 |
| ISSN: | 0894-8569 |
| Publisher: | Hindawi Publishing Corporation |
| Date Published: | 2000-01-01 |
| Start Page: | 383 |
| End Page: | 390 |
| Language: | English |
| PUBMED: | 10977117 |
| PROVIDER: | scopus |
| PMCID: | PMC2424001 |
| DOI: | 10.1155/2000/17619 |
| DOI/URL: | |
| Notes: | Export Date: 18 November 2015 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
Related MSK Work