Cytogenetic evidence of clonality in cutaneous benign fibrous histiocytomas: A report of the CHAMP study group Journal Article
| Authors: | Vanni, R.; Fletcher, C. D. M.; Sciot, R.; Dal Cin, P.; De Wever, I.; Mandahl, N.; Mertens, F.; Mitelman, F.; Rosai, J.; Rydholm, A.; Tallini, G.; Van Den Berghe, H.; Willén, H. |
| Article Title: | Cytogenetic evidence of clonality in cutaneous benign fibrous histiocytomas: A report of the CHAMP study group |
| Abstract: | Aims: Cutaneous benign fibrohistiocytic tumours are among the most common soft tissue lesions. Their biological nature, in particular whether they are neoplastic or reactive has long been disputed. Some morphological subtypes can be confused with sarcoma. Since available karyotypic data in these lesions are scarce, this study was undertaken to determine whether their cytogenetic analysis might demonstrate clonality and might help in differential diagnosis. Methods and results: Thirteen karyotyped benign cutaneous fibrous histiocytomas (BFH) were morphologically reassessed and classified as ordinary BFH (eight cases), cellular BFH (four cases), and one ankle-type lesion. Five cases (38%) showed clonal cytogenetic changes, although the aberrations varied and did not correlate with histological subtypes. Karyotypic aberrations were more common in cellular BFH (3/4) than in the ordinary BFH (2/8). Conclusions: The demonstration of clonal chromosome abnormalities, in at least some cases, supports the neoplastic nature of cutaneous BFH. The karyotypic changes identified are different from those in dermatofibrosarcoma, with which cellular BFH is often confused histologically. |
| Keywords: | adolescent; adult; child; clinical article; human tissue; aged; middle aged; histopathology; diagnostic procedure; skin neoplasms; differential diagnosis; cytogenetics; chromosome aberration; chromosome aberrations; dermatofibroma; morphometrics; chromosome analysis; karyotyping; tumor classification; clone cells; chromosome 17; cytogenetic analysis; chromosomes; chromosome 22; dermatofibrosarcoma protuberans; chromosome 4; histiocytoma, benign fibrous; chromosome 14; humans; human; male; female; priority journal; article; cutaneous fibrohistiocytic tumours |
| Journal Title: | Histopathology |
| Volume: | 37 |
| Issue: | 3 |
| ISSN: | 0309-0167 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2000-09-01 |
| Start Page: | 212 |
| End Page: | 217 |
| Language: | English |
| DOI: | 10.1046/j.1365-2559.2000.00947.x |
| PUBMED: | 10971696 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 18 November 2015 -- Source: Scopus |
