Presence of human papilloma virus in tumor tissue from children with retinoblastoma: An alternative mechanism for tumor development Journal Article
| Authors: | Orjuela, M.; Castaneda, V. P.; Ridaura, C.; Lecona, E.; Leal, C.; Abramson, D. H.; Orlow, I.; Gerald, W.; Cordon-Cardo, C. |
| Article Title: | Presence of human papilloma virus in tumor tissue from children with retinoblastoma: An alternative mechanism for tumor development |
| Abstract: | Epidemiological studies have shown that the use of barrier methods of contraception is associated with a decreased incidence of papilloma virus infection and reduced risk of having a child with retinoblastoma. Thirty-nine primary retinoblastomas were analyzed for the presence of papilloma virus sequences. Tumor tissue sections were also used to assess the expression of the retinoblastoma protein and proliferative index. Papilloma sequences were detected in 14 of 39 (36%) tumors. Tumors in which viral sequences were detected were associated with a lower proliferative index (68% versus 78%; P = 0.015). Children with tumors containing viral sequences had a lower risk of extraocular disease (odds ratio, 9.0; 95% confidence interval, 1.6-49; P = 0.008) and a lower birth weight (2.9 versus 3.5 kg; P = 0.030). Based on these data, it is our hypothesis that papilloma viruses may play a role in the development of sporadic retinoblastoma. Detection of papilloma virus sequences and retinoblastoma protein in certain primary lesions suggests an alternative mechanism of tumor development for sporadic retinoblastoma. |
| Keywords: | immunohistochemistry; child; clinical article; human tissue; child, preschool; dna-binding proteins; cancer incidence; polymerase chain reaction; cell cycle proteins; cell division; retinoblastoma; hela cells; risk factor; transcription factors; infant; uterine cervix cancer; carrier proteins; virus infection; retinoblastoma protein; age of onset; wart virus; hypothesis; transcription factor dp1; papillomaviridae; e2f transcription factors; blotting, southern; epidemiological data; contraception; extraocular muscle; humans; human; male; female; priority journal; article; birth weight |
| Journal Title: | Clinical Cancer Research |
| Volume: | 6 |
| Issue: | 10 |
| ISSN: | 1078-0432 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2000-10-01 |
| Start Page: | 4010 |
| End Page: | 4016 |
| Language: | English |
| PUBMED: | 11051250 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 18 November 2015 -- Source: Scopus |
