Sclerosing angiomatoid nodular transformation (SANT) of the spleen: A report of 3 cases Journal Article
| Authors: | Koreishi, A. F.; Saenz, A. J.; Fleming, S. E.; Teruya-Feldstein, J. |
| Article Title: | Sclerosing angiomatoid nodular transformation (SANT) of the spleen: A report of 3 cases |
| Abstract: | The authors describe 3 cases of sclerosing angiomatoid nodular transformation (SANT) of the spleen diagnosed at Memorial Sloan-Kettering Cancer Center within a 1-year period (July 2008 to June 2009). All patients were female, older than 50, with lesions ranging in size from 2 to 4 cm. All were alive and well after splenectomy. All the cases showed characteristic histological and immunophenotypical findings as previously described in the literature, including scattered IgG4positive plasma cells in the fibrosclerotic stroma. Of the 3 patients, 2 had a history of carcinoma, and metastasis was of concern, but a PET scan in one of these patients showed minimal to absent FDG activity suggesting that this process was of a benign indolent nature. However, in 1 patient, a PET scan revealed positive FDG activity, heightening clinical concern for malignancy. |
| Keywords: | adult; aged; disease-free survival; middle aged; splenectomy; case report; nuclear magnetic resonance imaging; positron emission tomography; follow up; cancer diagnosis; biological markers; spleen; tumor volume; abdominal pain; immunoglobulin g; carcinoma in situ; diabetes mellitus; fluorodeoxyglucose f 18; positron-emission tomography; nephroureterectomy; immunophenotyping; uterine tube carcinoma; hypothyroidism; hemangioma; hamartoma; pet scan; sant; sclerosing angiomatoid nodular transformation; immunoglobulin g4; sclerosing angiomatoid nodular transformation of the spleen; spleen tumor; spleen weight; vascular lesion; plasma cells; sclerosis; splenic neoplasms |
| Journal Title: | International Journal of Surgical Pathology |
| Volume: | 17 |
| Issue: | 5 |
| ISSN: | 1066-8969 |
| Publisher: | Sage Publications |
| Date Published: | 2009-10-01 |
| Start Page: | 384 |
| End Page: | 389 |
| Language: | English |
| DOI: | 10.1177/1066896909342568 |
| PUBMED: | 19666947 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 30 November 2010" - "CODEN: IJSPF" - "Source: Scopus" |
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