Dermatofibrosarcoma protuberans of the head and neck Journal Article
| Authors: | Stojadinovic, A.; Karpoff, H. M.; Antonescu, C. R.; Shah, J. P.; Singh, B.; Spiro, R. H.; Dumornay, W.; Shaha, A. R. |
| Article Title: | Dermatofibrosarcoma protuberans of the head and neck |
| Abstract: | Background: Dermatofibrosarcoma protuberans (DFSP) of the head and neck is a rare, locally infiltrative, low-grade sarcoma. This study defines the clinical behavior of DFSP, evaluates the role of frozen section analysis, and identifies factors that predict local control. Methods: Hospital records and pathological slides were reviewed for 33 patients with pathologically confirmed head and neck DFSP treated at Memorial Sloan-Kettering Cancer Center between 1964 and 1999. Factors were analyzed by using Fisher's exact or χ2 tests. Results: For 21 primary and 12 recurrent patients, median age and tumor size at presentation was 39 years and 2.0 cm, respectively. Thirty-two (97%) patients were alive at a median follow-up of 82 months. Three patients recurred locally, all with smaller than 2-cm resection margins. Deep tumors were more likely to have a margin-positive resection than superficial lesions (P = .03). Gross margin 2 cm or more was a significant predictor of a negative histological margin (P < .001). There was a trend toward improved recurrence-free survival for tumors treated with wide (≥2 cm) margin resection (P = .059). Accuracy, sensitivity, specificity, and false negative rates of frozen section were 80%, 43%, 100%, and 57%, respectively. Conclusions: Wide margin resection of head and neck DFSP predicts negative histological margins and impacts favorably on local recurrence-free survival. Frozen section analysis does not assess resection margins accurately. |
| Keywords: | adult; cancer survival; clinical article; human tissue; treatment outcome; aged; disease-free survival; middle aged; retrospective studies; mortality; cancer recurrence; disease free survival; follow up; follow-up studies; neoplasm recurrence, local; skin neoplasms; pathology; retrospective study; histology; sarcoma; skin tumor; fibrosarcoma; head and neck cancer; head and neck neoplasms; tumor recurrence; cancer size; medical record; frozen section; head and neck; frozen sections; head and neck tumor; dermatofibrosarcoma; medical records; dermatofibrosarcoma protuberans; humans; human; male; female; article |
| Journal Title: | Annals of Surgical Oncology |
| Volume: | 7 |
| Issue: | 9 |
| ISSN: | 1068-9265 |
| Publisher: | Springer |
| Date Published: | 2000-10-01 |
| Start Page: | 696 |
| End Page: | 704 |
| Language: | English |
| PUBMED: | 11034249 |
| PROVIDER: | scopus |
| DOI: | 10.1007/s10434-000-0696-3 |
| DOI/URL: | |
| Notes: | Export Date: 18 November 2015 -- Source: Scopus |
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